billybob

Hello all,

This afternoon I decided it was finally take the bull by the horns and
look for my copy of my post-op biopsy report amongst all of the stuff
I still need to sort through all the stuff moved after the roommates
moved in.

Unfortunately, I do not have a copy of my PSA's all together and
charted as I should.

I called my step-sister who is a pathologist and couldn't get a
straight answer (her husband who is almost 80 is going down-hill fast
from colon cancer so I am not that upset with her.)

But I am confused. I went in for the biopsy without any symptoms when
palpitating the prostate. The PSA was just barely at or above 4. So,
they did the six-needle biopsy and found diffused cancer in 2 of the 3
left side biopsies. 20 percent of the middle one and 10% of the top
one. That was Dec., 2000. Because of all the tests he wanted to run
and all of the other doctors I had to see - heart stress test, bone
scan, x-rays, look at my hip replacements, etc. and a month for my
Urologist to return home to India for a vacation, I did not have my RP
until March 12, 2001.

The PSA was 0.4 the first test after RP and then went to 0.1 three
months later. it went up and down from there but never got to 0.1
again if I remember correctly.

The post-op biopsy summary reads as follows:

[Begin quote]

Type: Adenocarcinoma
Grade: Moderately differentiated : (Gleason's 6/10)
(Is that 6:10 or 6 out of 10?)
Side: Left.
Margins: Left posterior involved.
Seminal Vesicle: Negative.

Comments:

The prostate shows a Gleason's 6/10 dissiminated prostatic
adenocarcinoma confined to the left lobe occupying approximately 20%
of that lobe by volume. There is penetration of the capsule with
involvement of perirostatc adipose tissue focally and there is focal
involvement of the linked psterior margin in the mid portion of the
left lobe. Both the right and left lymph nodes show very prominent
sinus histocytosis which may be related to the bilateral hip
replacements the patient has had.

[End quote]

I had my first bilateral replacements in Sept. & Oct., 1977 using glue
and wire and was walking on the new Charnely hips within a day or two.

However, in ****ysis of the right lymph nodes it was noted that
"scattered multinucleated cells in the hiatocites distended sinusus'
(holes or open) "are mostly or completely filled with histocytes"
(microphages or a type of white blood cells.) Some of the histocytes
on both sides have a "granular eosinophilic cytoplasm". On the left
side "occasional" multinucleated cells were seen.

The granulation suggest to me that this condition had been present for
a rather long time but the multinucleated cells bother me.

So, what do you people know of or think of this? Am I a T1c or a T2c?

Would really like to hear from a professional on this, if that is
possible.

By the way, when I got the results my step-sister said she had helped
supervise during residency the pathologist who did the P.O. path. and
that the person was one of the best she had seen.

======================

I am burned out and have my head spinning. For almost 12 hours I have
been reading messages and looking up web sites and info (which leads
to more searches) from this news group so I need to get my head out of
cancer and possibly into bed - if I can sleep with all the info I'm
trying to process.

I DID make it to the last 11 threads last posted to the group. less
than 50 posts.

Will probably get back to this late today or Monday.

Thank you all for being there. i have isolated too much with PCa and
osteo-arthritis cropping up in the last three years. I feel like my
brother in law did when he came back from Viet Nam - shell shocked.

Regards,

Jim

steve kramer

If I read it right, you would be a T2a, palpable; involves less than half of
one lobe of the prostate. Gleason scores are n of 5 plus n of 5 for a total
of n of 10. So, I'd say it's a 6. Sometimes, I've seen scores for each
lobe, but with no cancer in the one lobe, it cannot be a 6 and a 10.

--
Steve Kramer
PSA 16 10/17/2000 @ 46
Biopsy 11/01/2000 G7 (3+4), T2c
RRP 12/15/2000
PSA .1 .1 .1 .3 .4 .8
EBRT 05-07/2002 @ 47
PSA .3 .2 .2 .2 .3
Erection 05/12/2003 @ 48
HT 07/21&09/04/2003 @ 48

leonard evens

I am not a physician, but I think your prognosis is probably pretty
good. The signficant part of the post surgical pathlogy report is the
information that the tumor penetrated the prostate. Since your Gleason
was 6, that in itself is not reason for concern. It is hard to say
what the PSA readings mean since there is no much variation in how labs
do it and how they report it. You will have to rely on your doctor for
definitive information about that. You should really talk to him at
length about just how things seem, and in particular, you should ask him
if he envisions the possiblity of follow up radiation. My guess is
that there is nothing specially significant going on and you can just
forget the whole thing except for keeping up with your regular PSA
tests. But you really need to check that out with your doctor.

Best of luck.

--
Leonard Evens len@math.northwestern.edu 847-491-5537
Dept. of Mathematics, Northwestern Univ., Evanston, IL 60208