PSA confusion. - explantation (WARNING - long)
As far as I am concerned, Curtis, this is just a lively intellectual
discussion. Hopefully, someone in the NG including myself will find
something of value in it.
"i should have said that when male mormoes are shut of, the psa-making
process MAY stop instead of saying the psa-making process IS stopped.
btw, the reference to that is found in dr. walsh's book page 353"
That statement is indeed there and I admit I am a little perplexed by
it. It follows the statement that w/ HT the tumor shrinks and PSA
level drops, and I read that as being a cause and an effect - PSA
drops because the tumor has shrunk and there are fewer cells cranking
out PSA. However, he then states that PSA production [in
hormone-dependent cells] is controlled by hormones. This is indeed
support for your premise and I apologize for overlooking it. On the
other hand, I am not convinced it is biochemically correct so I will
try do some research on it. If that is right it would seem that there
should be a correlation between PSA and testosterone level in healthy
men but I am not aware of that being the case.
One thing is certain and that is that the human body is one heck of a
complicated piece of work and the further we get into it and begin to
learn what makes it tick, the more complicated we find it to be.
"the poster wanted to know that if medication that lowers psa would
affect cancer growth. i would still have to say yes. now, i noticed
that when you posted, you put word "or" in part of your answer. and
from that view point, may be why it is being seen like that."
I can't find the post now but I am pretty sure he asked if treatment
that lowers PSA affects cancer growth OR just lowers PSA.
"can you name or give an example of where you can lower psa levels and
NOT affect cancer growth? i will admit it, i could not."
Yes. Antibiotics like Cipro lower PSA in men w/ prostatitis but I
haven't heard that they have any affect on PCa. I think that is what
had the original poster confused - he may have heard about men
reducing their elevated PSA w/ Cipro and wondered if that was a PCa
treatment. That is why I was so quick to dispel any notion that PSA is
the target of PCa treatment. Other than that, I do not know of a
substance that directly lowers PSA w/o any effect on PCa, but it is
conceivable since [beating the dead horse one last time] PCa does not
need PSA to grow.
On another topic, do you or anyone know of an existing, umbrella PCa
support organization of which local chapters can be established?
Bill Denton
RP 2/12/02
Memphis
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