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1 21st June 03:50
palmer_ent
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Default science update - erections could be a sniff away


hi folks - here's the latest info on the leading edge on the battle for
erections.

a new type of erectile dysfunction drug that is delivered by nasal spray
shows promise in early clinical trails instead of directly affecting
affecting blood vessels in the penis as the currently available drugs
do. the novel treatment targets the brain - specifically, the region of
the brain that regulates ***ual response.

palatin technologies inc. said they plan to study the treatment in men
who either don't respond to or cannot take viagra or similarly acting
drugs for erectile dysfunction. they also plan to test it for ***ual
dysfunction in women and are searching for a corporate partner to help
them develop to market the drug, now known as PT -141.

FEW SIDE EFFECTS AT LOW DOSES

more trials of the drug in men with erectile dysfunction are scheduled
for completion late in 2006, and the company hopes to win FDA approval,
within the following year. if that happens, PT-141 could be the first
drug approved for erectile dysfunction that acts on the central nervous
system.

another central nervous system-acting drug. Uprima, was slated to
recommend the first real competitor to viagra until its manufacturer
withdrew it's application for FDA approval in the summer of 2000.
according to news accounts, one in 30 men who took the optimal dosage of
Uprima fainted or suffered severe low blood pressure as a result.

urologist and impotence researcher Harin Padma-Nathan, MD, who led
trials for both Uprima and PT-141, says low blood pressure was not seen
as a side effect in the 273 men taking part in the newly reported PT-141
trial.

"it was very clear that (PT-141) was very different from any other
centrally acting agent, " he said. thursday.

he added that side effects with the lowest doses of PT-141 were very
similar to what has been seen with viagra, levitra, and another drug
expected to win approval for the treatment of erectile dysfunction
called cialia. all three drugs work by increasing blood flow to the
penis, creating an erection.

PT-141 is in a new class of drugs that works on the part of the brain
involved in ***ual function.

GI PROBLEMS SEEN AT HIGHER DOSES

the men in the PT-141 trial who took the highest doses of the drug did
have an unacceptably high incidence of gastrointestinal side effects,
including nausea. they made up almost all of the roughly 12% of
patients who dropped out of the trial, and one researcher says future
studies will not include these higher doses.

those included in the trial had mild to severe erectile dysfunction, and
all had taken viagra prior to enrollment and had responded well to it.
the men took PT-141 via nose sprays at least three times, and some took
it as many as 10 times before reporting improved erections.

one in 10 men who received placebo treatments reported restoration of
normal erectile function, compared with roughly one in three patients
treated with the lowest dosage of PT-141 and one in two patients treated
with the highest dosage.

Palatin technologies CEO , carl spana, PHD, said men taking part in
future studies will be started off at the lowest dosage and dosages will
be increased gradually, if needed, to minimize side effects.

the company is also planning drug interaction studies evaluating the
safety of PT-141 in men using nitrate medications for heart disease,
viagra and similar drugs are not recommended for these patients, and
spana says they account for roughly 10% of men with erectile dysfunciton

"we have no reason to expect that PT-141 will interact with nitrates,"
he says, "this represents a significant potential advantage."

"right now in the united states we have viagra and levitra, and i expect
that cialis will soon be available," he says, "these are good drugs,
but they aren't perfect. they don't work for everybody, so having a
drug that works by a completely different mechanism of action is an
attractive prospect."


~ curtis

knowledge is power - growing old is mandatory - growing wise is optional
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2 23rd June 14:31
leonard evens
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Posts: 1
Default science update - erections could be a sniff away


This is all very interesting, but it does seem unclear how a drug
working through the central nervous system can help if the nerves
leading to the penis giverning erections are cut or damaged. Perhaps
many cases of impotence following treatment are caused by a variety of
factors, so such a drug might work. Viagra and similar drugs work,
when they do, by directly helping the biochemical changes which are
normally initiated through those nerves.
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3 23rd June 14:31
david s
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Default science update - erections could be a sniff away


2006 - that is pretty long foreplay....
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4 23rd June 14:32
jk
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Default science update - erections could be a sniff away


I'm not going to be the one to suggest what the scent should be.... but I
have an idea.


--
JK Sinrod NY
Sinrod Stained Glass
http://www.sinrodstudios.com
Coney Island Memories
http://www.sinrodstudios.com/coneymemories
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5 23rd June 14:32
palmer_ent
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Default science update - erections could be a sniff away


good one jk. that thought had crossed my mind too!!!

~ curtis

knowledge is power - growing old is mandatory - growing wise is optional
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6 26th June 17:55
steve kramer
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Default science update - erections could be a sniff away


For some reason, I'm thinking your not thinking lemon, pine or cherry
blossom.
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