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1 3rd June 23:30
ironjustice
External User
 
Posts: 1
Default Elevated aminotransferase / iron (stress hepatitis)


CONCLUSIONS: In this large, national, population-based study, the risk for
apparent liver injury was associated with increased iron and decreased
antioxidants, particularly carotenoids.

1: Gastroenterology. 2003 Jun;124(7):1821-9. Related Articles, Links


Relation of elevated serum alanine aminotransferase activity with iron and
antioxidant levels in the United States.

Ruhl CE, Everhart JE.

Social and Scientific Systems Inc., 8757 Ge****a Avenue, 12th Floor, Silver
Spring, MD 20910, USA. cruhl@s-3.com

BACKGROUND & AIMS: Oxidative stress is thought to play a role in liver injury.
Hepatic iron may promote liver injury, whereas antioxidant vitamins and
minerals may inhibit it, but few clinical studies have examined such
relationships. We ****yzed the associations of serum iron measures and
antioxidant concentrations with abnormal serum alanine transaminase (ALT)
activity in a large, national, population-based study. METHODS: A total of
13,605 adult participants in the third U.S. National Health and Nutrition
Examination Survey (NHANES III), 1988-1994, underwent phlebotomy. Exclusions
included excessive alcohol consumption, hepatitis B and C, and iron overload.
RESULTS: Elevated ALT levels were found in 3.1% of the population. In
univariate ****ysis, factors associated with abnormal ALT levels (P < 0.05)
included higher transferrin saturation and iron and selenium concentrations,
and lower vitamin C, alpha and beta carotene, and lutein/zeaxanthin
concentrations. In multivariate logistic regression ****yses, elevated ALT
level was associated positively with increasing deciles of transferrin
saturation (odds ratio [OR] per decile, 1.10; 95% confidence interval [CI],
1.03-1.18) and iron concentration (OR, 1.13; 95% CI, 1.06-1.21). Abnormal ALT
level was associated negatively with increasing deciles of alpha carotene (OR,
0.82; 95% CI, 0.72-0.94), beta carotene (OR, 0.91; 95% CI, 0.86-0.96), beta
cryptoxanthin (OR, 0.91; 95% CI, 0.84-0.99), lutein/zeaxanthin (OR, 0.90; 95%
CI, 0.84-0.96), and a variable combining the 5 carotenoid measures (OR, 0.89;
95% CI, 0.83-0.95). Vitamin C was associated inversely, but only at the highest
concentrations. CONCLUSIONS: In this large, national, population-based study,
the risk for apparent liver injury was associated with increased iron and
decreased antioxidants, particularly carotenoids.

PMID: 12806616 [PubMed - indexed for MEDLINE]

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2 3rd June 23:30
ironjustice
External User
 
Posts: 1
Default Elevated aminotransferase / iron (stress hepatitis)


CONCLUSIONS: In this large, national, population-based study, the risk for
apparent liver injury was associated with increased iron and decreased
antioxidants, particularly carotenoids.

1: Gastroenterology. 2003 Jun;124(7):1821-9. Related Articles, Links


Relation of elevated serum alanine aminotransferase activity with iron and
antioxidant levels in the United States.

Ruhl CE, Everhart JE.

Social and Scientific Systems Inc., 8757 Ge****a Avenue, 12th Floor, Silver
Spring, MD 20910, USA. cruhl@s-3.com

BACKGROUND & AIMS: Oxidative stress is thought to play a role in liver injury.
Hepatic iron may promote liver injury, whereas antioxidant vitamins and
minerals may inhibit it, but few clinical studies have examined such
relationships. We ****yzed the associations of serum iron measures and
antioxidant concentrations with abnormal serum alanine transaminase (ALT)
activity in a large, national, population-based study. METHODS: A total of
13,605 adult participants in the third U.S. National Health and Nutrition
Examination Survey (NHANES III), 1988-1994, underwent phlebotomy. Exclusions
included excessive alcohol consumption, hepatitis B and C, and iron overload.
RESULTS: Elevated ALT levels were found in 3.1% of the population. In
univariate ****ysis, factors associated with abnormal ALT levels (P < 0.05)
included higher transferrin saturation and iron and selenium concentrations,
and lower vitamin C, alpha and beta carotene, and lutein/zeaxanthin
concentrations. In multivariate logistic regression ****yses, elevated ALT
level was associated positively with increasing deciles of transferrin
saturation (odds ratio [OR] per decile, 1.10; 95% confidence interval [CI],
1.03-1.18) and iron concentration (OR, 1.13; 95% CI, 1.06-1.21). Abnormal ALT
level was associated negatively with increasing deciles of alpha carotene (OR,
0.82; 95% CI, 0.72-0.94), beta carotene (OR, 0.91; 95% CI, 0.86-0.96), beta
cryptoxanthin (OR, 0.91; 95% CI, 0.84-0.99), lutein/zeaxanthin (OR, 0.90; 95%
CI, 0.84-0.96), and a variable combining the 5 carotenoid measures (OR, 0.89;
95% CI, 0.83-0.95). Vitamin C was associated inversely, but only at the highest
concentrations. CONCLUSIONS: In this large, national, population-based study,
the risk for apparent liver injury was associated with increased iron and
decreased antioxidants, particularly carotenoids.

PMID: 12806616 [PubMed - indexed for MEDLINE]

--------------------------------------------------------------------------
------

Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking
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3 3rd June 23:31
External User
 
Posts: 1
Default Elevated aminotransferase / iron


Hey, Doe. You mind sending that article to my email address. I want to
send it to a friend of mine. Thanks!!

Elmo

http://community.webtv.net/elmoemerson/DocElmosHepFile
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4 3rd June 23:31
External User
 
Posts: 1
Default Elevated aminotransferase / iron


Hey, Doe. You mind sending that article to my email address. I want to
send it to a friend of mine. Thanks!!

Elmo

http://community.webtv.net/elmoemerson/DocElmosHepFile
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5 7th June 15:08
waterspider
External User
 
Posts: 1
Default Elevated aminotransferase / iron


| Hey, Doe. You mind sending that article to my email address. I want to
| send it to a friend of mine. Thanks!!
|
Don't forget to point out that the study excluded heppers.
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