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New drug lowers post-heart transplant recovery risk

ANI
Thursday, August 28, 2003

Washington - New research shows that Everolimus, a new
immuno-suppressant drug, can effectively reduce post-
heart transplant complications.

According to a report appearing in the August issue of
the New England Journal of Medicine, the study targetted
the impact of Everolimus on certain complications like
acute rejection and cardiac allograft vasculopathy, where
the innermost wall of the transplanted heart's coronary
arteries thickens and restricts blood flow.

"After one year post-transplant, cardiac allograft
vasculopathy is the most serious cause of long-term
complications and death. It is the major reason why many
transplant patients do not survive long term," Howard
Eisen, principal investigator and director at the
Advanced Heart Failure Center at Temple University
Hospital and School of Medicine, said.

Hailing the results, Howard said that transplant patients
now had a powerful tool to improve their chances of
survival. Further, Everolimus also reduces the rate of
acute rejection, which is considered a major problem in
the first year after a transplant is carried out.

More than 600 cardiac transplantation patients at 52
medical centers in the United States, Canada, Europe and
South America participated in the study. The researchers
also reported that Everolimus significantly reduced the
risk of cytomegalovirus infection, a major infection
post-transplant.

Developed by Novartis, the drug has been submitted for
regulatory review in both kidney and heart
transplantation use in the US, Canada and the European
Union.

During the yearlong ****ysis of heart transplant
patients, Howard and his team do***ented their regimen
with Everolimus. Giving doses of either 3.0 or 1.5
milligrams per day, it was found that the incidence of
acute rejection episodes reduced considerably.

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