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Serum ferritin concentration had statistically significant (p <.05) direct
correlations with most of the measured oxysterols
<<snip>>


Free Radic Biol Med. 2003 Oct 15;35(8):922-8. Links


Serum ferritin concentration is associated with plasma levels of cholesterol
oxidation products in man.

Tuomainen TP, Diczfalusy U, Kaikkonen J, Nyyssonen K, Salonen JT.

Research Institute of Public Health, University of Kuopio, Kuopio, Finland

Cholesterol oxidation products, oxysterols, are thought to play a part in the
initiation and development of human atherosclerotic lesions. Excessive body
iron has been suggested to promote atherosclerosis and coronary heart disease
through its pro-oxidative properties. In the present study, the associations
between serum ferritin and plasma oxysterol concentrations were examined in 669
eastern Finnish men. Serum ferritin concentration had statistically significant
(p <.05) direct correlations with most of the measured oxysterols. In
multivariate adjusted regression models, serum ferritin concentration predicted
significantly the levels of 27-hydroxycholesterol (beta = 0.13, p <.001),
7alpha-hydroxycholesterol (beta = 0.11, p =.005), 25-hydroxycholesterol (beta =
0.10, p =.007), 7-ketocholesterol (beta = 0.10, p =.009), and
7beta-hydroxycholesterol (beta = 0.10, p =.02). In conclusion, excess body
iron, as assessed by serum ferritin, is associated with increased levels of
circulating oxysterols, both of enzymatic and nonenzymatic origin, in man.

PMID: 14556856 [PubMed - in process]

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