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1: J Am Diet Assoc. 2003 May;103(5):577-81. Related Articles, Links


Fat-free foods supplemented with soy stanol-lecithin powder reduce cholesterol
absorption and LDL cholesterol.

Spilburg CA, Goldberg AC, McGill JB, Stenson WF, Racette SB, Bateman J,
McPherson TB, Ostlund RE Jr.

Lifeline Technologies, Chesterfield, MO 63017, USA. Spilburg@aol.com

OBJECTIVE: The objective of this work was to show that fat-free,
lecithin-formulated soy stanols lower cholesterol absorption and serum LDL
cholesterol. DESIGN: Reduction in cholesterol absorption was measured in paired
single-meal tests with or without formulated soy stanols (acute test), and
changes in serum lipids were investigated in a 10-week, randomized,
double-blind parallel trial in which formulated stanols or lecithin vehicle
were given three times daily for the last 4 weeks (chronic test).
SUBJECTS/SETTING: Forty-five normal or mildly hypercholesterolemic subjects
were recruited for both studies. The 21 subjects (16 female, 5 male; mean age
32.5 years) in the absorption studies had the following mean lipid values: LDL
cholesterol, 2.79 mmol/L and total cholesterol, 4.73 mmol/L. For the lipid
reduction, 24 subjects (16 female, 8 male; mean age 50.6 years) were enrolled
with mean LDL cholesterol and total cholesterol of 3.72 mmol/L and 5.66 mmol/L,
respectively. INTERVENTION: Reduction in cholesterol absorption was measured
using a lemonade beverage or egg whites that contained 625 mg stanols.
Throughout the chronic study, subjects followed the American Heart Association
Step I diet. During the 4-week treatment phase, subjects consumed daily a
lemonade-flavored beverage containing either placebo or formulated soy stanols
(1.9 g). MAIN OUTCOME MEASURES: Inhibition of cholesterol absorption was
determined from the difference in plasma deuterated cholesterol enrichment
after a test meal containing stanol-lecithin and one with lecithin vehicle
only. In the chronic study, the primary endpoints were changes in LDL and total
cholesterol. STATISTICAL ****YSES PERFORMED: Paired or unpaired t tests were
used to determine statistical significance. RESULTS: Stanol-lecithin reduced
cholesterol absorption by 32.1% (P=.0045, n=10) and by 38.2% (P=.0022, n=11)
when delivered in a lemonade-flavored beverage and in egg whites, respectively.
Reduction in cholesterol absorption was strongly related to the initial level
of absorbed cholesterol tracer in serum (r(s)=-0.739). Stanol-lecithin given in
a beverage reduced total serum cholesterol by 10.1% (P=.0019, n=24) and LDL
cholesterol by 14.3% (P=.0016, n=24). APPLICATIONS/CONCLUSIONS: Powdered soy
stanol-lecithin lowers cholesterol absorption and LDL cholesterol when consumed
in fat-free foods.

Publication Types:
Clinical Trial
Randomized Controlled Trial

PMID: 12728215 [PubMed - indexed for MEDLINE]

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