ironjustice

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It doesn't really say WHEN he began to take the form of a woman..

ALL of the above are considered to be a sign of elevated iron levels in the
body.

At one time before the advent of hormone replacement therapy the ONLY treatment
which had an effect on the hypogonadism and gynecomastia was .. iron reduction
therapy / phlebotomy / bloodletting.

Am J Epidemiol. 2001 Aug 1;154(3):193-206. Related Articles, Links


HFE gene and hereditary hemochromatosis: a HuGE review. Human Genome
Epidemiology.

Hanson EH, Imperatore G, Burke W.

United States Air Force School of Aerospace Medicine, Brooks Air Force Base,
San Antonio, TX, USA. erichansonmdmph@yahoo.com

Hereditary hemochromatosis (HHC) is an autosomal recessive disorder of iron
metabolism characterized by increased iron absorption and deposition in the
liver, pancreas, heart, joints, and pituitary gland. Without treatment, death
may occur from cirrhosis, primary liver cancer, diabetes, or cardiomyopathy. In
1996, HFE, the gene for HHC, was mapped on the short arm of chromosome 6
(6p21.3). Two of the 37 allelic variants of HFE described to date (C282Y and
H63D) are significantly correlated with HHC. Homozygosity for the C282Y
mutation was found in 52-100% of previous studies on clinically diagnosed
probands. In this review, 5% of HHC probands were found to be compound
heterozygotes (C282Y/H63D), and 1.5% were homozygous for the H63D mutation;
3.6% were C282Y heterozygotes, and 5.2% were H63D heterozygotes. In 7% of
cases, C282Y and H63D mutations were not present. In the general population,
the frequency of the C282Y/C282Y genotype is 0.4%. C282Y heterozygosity ranges
from 9.2% in Europeans to nil in Asian, Indian subcontinent, African/Middle
Eastern, and Australasian populations. The H63D carrier frequency is 22% in
European populations. Accurate data on the penetrance of the different HFE
genotypes are not available. Extrapolating from limited clinical observations
in screening studies, an estimated 40--70% of persons with the C282Y homozygous
genotype will develop clinical evidence of iron overload. A smaller proportion
will die from complications of iron overload. To date, population screening for
HHC is not recommended because of uncertainties about optimal screening
strategies, optimal care for susceptible persons, laboratory standardization,
and the potential for stigmatization or discrimination.

Publication Types:
Review
Review, Tutorial

PMID: 11479183 [PubMed - indexed for MEDLINE]

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Who loves ya.
Tom

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