Iron / hepatitis / HIV / antioxidant depletion / repletion
BOTH hepatitis and HIV .. load .. iron ..
http://tinyurl.com/6yrs6
http://tinyurl.com/66sbh
Iron oxidizes / rusts .. destroying antioxidants .
http://tinyurl.com/57v6j
<<snip>>
considerable benefit should accrue from antioxidant repletion at dosages
substantially above recommended daily allowances (RDAs)
<<snip>>
Exp Mol Pathol. 2004 Oct;77(2):121-32. Related Articles, Links
Oxidative stress in viral hepatitis and AIDS.
Stehbens WE.
Department of Pathology and Molecular Medicine, Wellington School of Medicine
and Health Sciences, Wellington, New Zealand.
Dominant types of viral hepatitis are presently A, B, and C with prophylactic
immunization available only for A and B. Hepatitis B and C and human
immunodeficiency virus (HIV) infection constitute a worldwide scourge and
treatment is far from satisfactory. Each produces severe oxidative stress (OS)
and secondary cellular damage of varying severity and, as in toxic hepatitis,
progression and regression are dependent on redox balance between oxidation and
antioxidation. Experimental and clinical studies suggest that xenobiotics and
coinfections exert ***ulative, detrimental effects on their pathogeneses and
further deplete antioxidants. It is proposed therefore that in the clinical
management of these infections and especially in their early stages,
considerable benefit should accrue from antioxidant repletion at dosages
substantially above recommended daily allowances (RDAs) in conjunction with a
nutritious high protein diet. Because plasma zinc and selenium concentrations
are very low, their replenishment by high dosages is urgent and mandatory
particularly in advanced HIV infections bordering on acrodermatitis
enteropathica. Also recommended is their long-term continuance at high normal
levels.
PMID: 15351235 [PubMed - in process]
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Tom
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