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1 4th April 23:32
ironjustice
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Posts: 1
Default All anti-inflammatory drugs (diclofenac piroxicam in vitro)


Xenobiotica. 1988 Apr;18(4):459-70. Related Articles, Links


The iron-binding and hydroxyl radical scavenging action of anti-inflammatory
drugs.

Aruoma OI, Halliwell B.

Department of Biochemistry, University of London King's College, Strand Campus,
UK.

1. Hydroxyl radicals (.OH) are thought to be generated at sites of inflammation
and to contribute to tissue damage. All anti-inflammatory drugs tested were
able to scavenge .OH generated in free solution at almost diffusion-controlled
rates (rate constants about 10(10)M-1s-1). 2. Much .OH generation in vivo
occurs at specific sites, where bound metal ions (such as Fe2+) react with H2O2
to produce .OH that immediately attacks the site. Only .OH scavengers that have
sufficient metal-binding ability to withdraw metal ions from this site can
protect against site-specific damage. 3. All anti-inflammatory drugs tested
were able to protect against site-specific damage by .OH in a simple model
system in vitro. Penicillamine, diclofenac sodium, piroxicam, azathioprine,
primaquine, chloroquine and hydroxychloroquine were especially effective. 4.
The ability of an anti-inflammatory drug to protect against .OH formation in
vivo depends not only on its rate constant for reaction with .OH, but also on
its metal-binding ability and on the geometry and redox potential of any metal
complex formed.

PMID: 3135672 [PubMed - indexed for MEDLINE]

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2 17th May 06:02
ironjustice
External User
 
Posts: 1
Default All anti-inflammatory drugs (diclofenac piroxicam in vitro)


Xenobiotica. 1988 Apr;18(4):459-70. Related Articles, Links


The iron-binding and hydroxyl radical scavenging action of anti-inflammatory
drugs.

Aruoma OI, Halliwell B.

Department of Biochemistry, University of London King's College, Strand Campus,
UK.

1. Hydroxyl radicals (.OH) are thought to be generated at sites of inflammation
and to contribute to tissue damage. All anti-inflammatory drugs tested were
able to scavenge .OH generated in free solution at almost diffusion-controlled
rates (rate constants about 10(10)M-1s-1). 2. Much .OH generation in vivo
occurs at specific sites, where bound metal ions (such as Fe2+) react with H2O2
to produce .OH that immediately attacks the site. Only .OH scavengers that have
sufficient metal-binding ability to withdraw metal ions from this site can
protect against site-specific damage. 3. All anti-inflammatory drugs tested
were able to protect against site-specific damage by .OH in a simple model
system in vitro. Penicillamine, diclofenac sodium, piroxicam, azathioprine,
primaquine, chloroquine and hydroxychloroquine were especially effective. 4.
The ability of an anti-inflammatory drug to protect against .OH formation in
vivo depends not only on its rate constant for reaction with .OH, but also on
its metal-binding ability and on the geometry and redox potential of any metal
complex formed.

PMID: 3135672 [PubMed - indexed for MEDLINE]

--------------------------------------------------------------------------
------

Who loves ya.
Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking
  Reply With Quote
3 23rd May 04:34
ironjustice
External User
 
Posts: 1
Default All anti-inflammatory drugs (diclofenac piroxicam in vitro)


Xenobiotica. 1988 Apr;18(4):459-70. Related Articles, Links


The iron-binding and hydroxyl radical scavenging action of anti-inflammatory
drugs.

Aruoma OI, Halliwell B.

Department of Biochemistry, University of London King's College, Strand Campus,
UK.

1. Hydroxyl radicals (.OH) are thought to be generated at sites of inflammation
and to contribute to tissue damage. All anti-inflammatory drugs tested were
able to scavenge .OH generated in free solution at almost diffusion-controlled
rates (rate constants about 10(10)M-1s-1). 2. Much .OH generation in vivo
occurs at specific sites, where bound metal ions (such as Fe2+) react with H2O2
to produce .OH that immediately attacks the site. Only .OH scavengers that have
sufficient metal-binding ability to withdraw metal ions from this site can
protect against site-specific damage. 3. All anti-inflammatory drugs tested
were able to protect against site-specific damage by .OH in a simple model
system in vitro. Penicillamine, diclofenac sodium, piroxicam, azathioprine,
primaquine, chloroquine and hydroxychloroquine were especially effective. 4.
The ability of an anti-inflammatory drug to protect against .OH formation in
vivo depends not only on its rate constant for reaction with .OH, but also on
its metal-binding ability and on the geometry and redox potential of any metal
complex formed.

PMID: 3135672 [PubMed - indexed for MEDLINE]

--------------------------------------------------------------------------
------

Who loves ya.
Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking
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