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Anticancer Res. 2003 Nov-Dec;23(6D):5107-9. Links


Serum parameters of iron metabolism in patients with breast cancer.

Ulbrich EJ, Lebrecht A, Schneider I, Ludwig E, Koelbl H, Hefler LA.

Department of Obstetrics and Gynecology, Martin-Luther-University
Halle-Wittenberg, Magdeburger Strasse 24, 06097 Halle, Germany.
eva.ulbrich@medizin.uni-halle.de

BACKGROUND: The aim of our study was to determine the incidence of anemia as
evidenced by altered serum levels of iron metabolism in patients with breast
cancer (n = 84), ductal carcinoma in situ (DCIS) (n = 29), fibroadenoma (n =
100) and healthy women (n = 14). MATERIALS AND METHODS: Hemoglobin (Hb), serum
iron, serum ferritin, serum transferrin and serum transferrin receptor were
evaluated prior to surgery. No patient with breast cancer had anemia according
to Hb level. RESULTS: No significant correlations between serum iron,
transferrin and transferrin receptor were ascertained. Serum ferritin was
significantly elevated in patients with breast cancer. Among patients with
breast cancer, a significant correlation with positive lymph node involvement
was noted. CONCLUSION: Elevated serum ferritin might indicate the presence of
malignant disease and could be regarded as a predictor of positive lymph node
involvement in patients with breast cancer.

PMID: 14981974 [PubMed - in process]

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