ironjustice

Since iron decreases erythropoietin .. and since iron overload has
been shown IN .. Friedreich's Ataxia .. one might wonder if reduction
of iron would NOW .. kickstart .. everything .. ? .. just like in ..
leukemia .. ? .. somewhat like the choke on your .. ride .. ?

<<snip>>
persistent and significant increase in frataxin levels
<<snip>>

Ann Neurol. 2007 Aug 13; [Epub ahead of print] Links
Friedreich's ataxia: clinical pilot trial with recombinant human
erythropoietin.Boesch S, Sturm B, Hering S, Goldenberg H, Poewe W,
Scheiber-Mojdehkar B.
Department of Neurology, Innsbruck Medical University, Innsbruck,
Austria.

To determine the role of recombinant human erythropoietin as a
possible treatment option in Friedreich's ataxia, we performed an open-
label clinical pilot study. Primary outcome measure was the change of
frataxin levels at week 8 versus baseline. Twelve Friedreich's ataxia
patients received 5,000 units recombinant human erythropoietin three
times weekly subcutaneously. Frataxin levels were measured in isolated
lymphocytes by enzyme-linked immunosorbent assay. In addition, urinary
8-hydroxydeoxyguanosine and serum peroxides, were measured. Treatment
with recombinant human erythropoietin showed a persistent and
significant increase in frataxin levels after 8 weeks (p < 0.01). All
patients showed a reduction of oxidative stress markers. Ann Neurol
2007.

PMID: 17702040 [PubMed - as supplied by publisher]


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