30th June 22:23
High prevalence of Chlamydia pneumoniae antibodies and increased high-sensitive C-reactive protein in patients with vascular dementia. (dementia antibodies hemoglobin cholesterol atherosclerosis)
Yamamoto H, Watanabe T, Miyazaki A, Katagiri T, Idei T, Iguchi T,
Mimura M, Kamijima K.
Department of Neuropsychiatry, Showa University School of Medicine,
1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan.
OBJECTIVES: To determine the relationships between Chlamydia pneumoniae
infection, carotid atherosclerosis, and dyslipidemia in patients with
vascular dementia (VaD) and Alzheimer's disease (AD). DESIGN: Case
control study. SETTING: Showa University Karasuyama Hospital, Tokyo,
Japan. PARTICIPANTS: One hundred twenty-four elderly subjects: 31 with
VaD, 61 with AD, and 32 age-matched controls without dementia.
MEASUREMENTS: Presence of antibodies to C. pneumoniae (immunoglobulin G
(IgG) and IgA), the serum concentrations of high-sensitive C-reactive
protein (hs-CRP) and atherogenic lipoproteins, and the carotid artery
intima-media thickness (IMT) and plaques were determined. RESULTS: Age;
body mass index; systolic and diastolic blood pressures; and fasting
plasma glucose, hemoglobin A(1c), high-density lipoprotein cholesterol,
and apolipoprotein A-I, B, and E concentrations did not differ
significantly between the three groups, but the mean IMT and frequency
of atherosclerotic plaques in the carotid arteries, as well as the
serum concentrations of low-density lipoprotein cholesterol (LDL-C),
lipoprotein(a), and lipid peroxides were significantly greater in VaD
patients than in AD patients or nondemented controls. Hs-CRP
concentrations and prevalence of C. pneumoniae IgG and IgA antibodies
also were significantly higher in VaD patients than in AD patients and
nondemented controls. Multiple logistic regression ****ysis revealed
that carotid IMT and plaques, LDL-C, lipid peroxides, hs-CRP, and IgG
and IgA C. pneumoniae seropositivity were independent risk factors for
VaD. CONCLUSION: These results suggest that carotid atherosclerosis,
atherogenic lipoproteins, and C. pneumoniae infection (as do***ented by
the IgG and IgA seropositivity together with increased hs-CRP) may be
VaD risk factors.