ironjustice

Increased iron decreases .. erythropoietin .. and coincidentally iron
chelation extends life by five times in these patients.

Sooo .. giving credence to the iron ... ALREADY .. being .. there and
CAUSING the problems as opposed to being .. secondary / caused BY
transfusions.

Future Oncol. 2007 Aug;3(4):397-403. Links
Erythropoiesis-stimulating agents versus RBC transfusion in MDS:
comparison of long-term outcomes.Mundle SD.
OrthoBiotech Clinical Affairs LLC, Bridgewater, NJ, USA and, Rush
University Medical Center, 743 Knoch Knolls Road, Naperville, IL
60565, USA. suneelmundle@hotmail.com.

Impaired erythropoiesis and refractory anemia are clinical hallmarks
of the myelodysplastic syndromes (MDS). As the disease evolves, a
steady decline in hemoglobin in these disorders invariably results in
dependence on packed red blood cell (PRBC) transfusion. Such chronic
transfusion dependence has been associated with iron overload causing
cardio-hepatic toxicity and alloimmunization, and can result in
reduced survival in these patients. The use of hematopoietic growth
factors, particularly erythropoiesis-stimulating agents (ESAs), has
been reported to reduce the need for PRBC transfusion, raise
hemoglobin and improve quality of life, at least in patients
responding to such a therapy. Importantly, the clinical benefits of
ESA are well balanced, with an apparently favorable safety profile in
MDS, thus providing an eminent the****utic option to delay or avoid
transfusion dependence in these patients. The present report provides
a detailed comparative profile of long-term PRBC transfusions and the
balance of clinical benefits versus risks associated with ESA therapy
for MDS.

PMID: 17661714 [PubMed - in process]

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ironjustice

This article shows the mechanism of erythropoietin .
It frees up iron .. WHEN the iron is already there .
The previous article .. found iron by simply giving ..
erythropoietin ..

Iron is ALREADY there .
SHOWING clearly .. iron seems NOT .. not .. **NOT** .. to BE ..
'deficient'.

Hemoglobin. 2006;30(1):105-12. Links
Erythropoietin administration may potentiate mobilization of storage
iron in patients on oral iron chelation therapy.Cermák J.
Institute of Hematology & Blood Transfusion, Prague, Czech Republic.
cermak@uhkt.cz

Five, repeatedly transfused, patients with refractory anemia (RA) or
RA with ringed sideroblast (RARS) subtypes of myelodysplastic syndrome
(MDS), with serum ferritin (SF) levels of > 2,000 microg/L, and one
female with Hb E [beta26(B8)Glu --> Lys]/beta0-thalassemia (thal) with
an SF level of 1,760 microg/ L, were treated with deferiprone (L1) at
the dose of 4-6 g per day for at least 26 months. Beginning in the
second month, all patients received recombinant human erythropoietin
(rHuEPO) at the dose of 150 IU/kg thrice weekly, subcutaneously for 24
months. A significant increase in iron excretion after combined
administration of L1 and rHuEPO compared to treatment with L1 as a
single agent, was observed in all patients. The amount of excreted
iron in urine ranged from 7.5 to almost 20 mg per day. In one patient,
a response to rHuEPO resulted in transfusion independence and her SF
decreased from 2086 to 879 microg/L. In four MDS patients, who
remained dependent on red blood cell (RBC) transfusions, simultaneous
administration of L1 and rHuEPO enabled the stabilization of SF
levels, despite continuing iron load from the transfusions. Combined
administration of rHuEPO and oral iron chelators may potentiate
mobilization of storage iron and maintain iron balance in transfusion-
dependent iron overloaded early MDS patients.

PMID: 16540422 [PubMed - indexed for MEDLINE]


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DEAD PEOPLE WALKING
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