pro-humanist freelover

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March 24, 2010

New Form of Insulin Can Be Inhaled
Rather Than Injected
http://www.sciencedaily.com/releases/2010/03/100323133041.htm
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ScienceDaily (Mar. 24, 2010) - Scientists have described
a new ultra-rapid acting mealtime insulin (Afrezza) that
is orally inhaled for absorption via the lung.

Because the insulin is absorbed so rapidly, Afrezza's
profile closely mimics the normal early insulin response seen
in healthy individuals.

Afrezza is awaiting approval by the U. S. Food and Drug
Administration (FDA). This presentation took place at the
239th American Chemical Society National Meeting, being
held in San Francisco, California, USA March 21-25.

Andrea Leone-Bay, Ph.D. and colleagues at MannKind
Corporation said that the new insulin product, uses the
Technosphere® technology, a delivery technology that is
applicable to a wide variety of other drugs that are currently
injected. Like insulin, these medications are proteins that
would be digested and destroyed in the stomach if taken
by mouth.

....

Afreeza (insulin human rDNA origin) Inhalation Powder is
an ultra-rapid acting insulin intended for use at mealtime to
control the rapid rise in blood sugar levels that occurs ...
immediately after a meal. ...

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References:

What is Insulinitis?
http://prohuman.net/insulinitis.htm

What is Cellosis?
http://prohuman.net/cellosis.htm

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nico kadel-garcia

"Bullwinkle, that trick *NEVER* works!!!"

Inhaled insulin has been promised for over 30 years, with the first
vaguely successful experiments appartnely in 1971. Guess what? It
doesn't work! Dosage control is too erratic, and effect on the lungs
has also been a very serious safety concern. (Exubera, a previous
version of inhaled insulin, was linked to lung cancer in various
studies.) So yet another company trying to pull venture capital for
yet another slightly different inhaled insulin should be treated much
as we treat the non-invaasive glucometers: with a strong dose of
skepticism, and a good look at the company's books and actual test
results, rather than the excitement of their press releases.

FREELOVER, you don't seem malicious, but please don't believe
everything you read from these press releases. Look into the history
of these EXCITING!!!! NEW!!! CLAIMS!!!!

pro-humanist freelover

"Nico Kadel-Garcia" <nkadel@gmail.com> wrote ...

The FDA is currently reviewing Afreeza. As for hope,
it would only be used in place of mealtime insulin,
replacing insulin injections for users of substances
like Regular insulin and Novolog (i.e., the quicker
acting short-term insulins). It would only be available
if it passes the FDA review process. It would not
replace long-term insulin injections, the once or twice
daily injections used in most Insulintis (aka, type 1
diabetes) treatments. It would not reduce the number
of finger-pricks folks use to test their glucose levels.

So, just one example, I most often use 6 insulin injec-
tions and 4 finger-pricks per day. If Afreeza was
approved, I'd be on 2 insulin injections, 4 insulin
inhalations, and 4 finger-pricks per day. Will it
occur? Don't know. Will it be safe? I'd have to
research that further, were it to get FDA approval,
but as of yet, being that it hasn't been approved,
I'm intrigued. The information on past failures, I'd
be remiss if I failed to take that into consideration
if Afreeza becomes available, and I'd have to ascer-
tain the FDA position on the matter before gaining
any confidence in trying it, were it to become avail-
able.

Thanks for your informative response.

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julie bove

Just curious... How can you do 6 insulin injections if you are only doing 4
BG tests per day? I test each time I do insulin. Most days that is 4
injections. I take my Lantus twice daily and eat 2 meals on most days.
Generally do not do insulin with snacks unless my BG is overly high. It
usually is not at snack time.

I have been told that my cousin's son does inhaled insulin. He is a child.
Type 1. I don't know the particulars. He lives in another state. I fail
to see how this would work for him, given what I know about it.

As for inhaling stuff... I was prescribed an inhaler last year due to
pneumonia followed by bronchitis. The inhaler was not fun. No it was not.
It was about as much fun as stabbing myself with a needle. Not that I enjoy
stabbing myself with a needle. I just guess from my perspective, I'd just
as soon stab myself than have to inhale something that in and of itself can
cause problems by the method of delivery (inhalation). Now if they could
put insulin in a pill? Oh joy!

nick cramer

Sweetbreads?

--
Nick, KI6VAV. Support severely wounded and disabled Veterans and their
families: https://www.woundedwarriorproject.org/ Thank a Veteran!
Support Our Troops: http://anymarine.com/ You are not forgotten.
Thanks ! ! ~Semper Fi~ USMC 1365061

julie bove

No. Insulin.

màck©®

Pardon? Yu are injection some of those doses without knowing what
your BG is?

Are you even diabetic? Or just faking it?

màck©®

Or you are injecting Lantus or it's equal separate from one of the
fast acting insulin and NOT testing after you eat.

Again not the correct approach for a type 1.

alan mackenzie

Not necessarily. If 2 of these jabs are of basal, they could be being
done at the same time as 2 boluses (?boli?).

Anyhow, we all just do what works, what is the least bad. Being diabetic
for ~50 years, he'll know all about injecting insulin without knowing his
BG to 3 significant figures.


I think he is. Have a look at his web site; faking that much would be
too much effort for a troll.

--
Alan Mackenzie (Nuremberg, Germany).

alan mackenzie

There is no one single "correct" approach. We all do what we have to,
what is the least bad, and that varies between us. What works for you
wouldn't work for me, and vice versa.

--
Alan Mackenzie (Nuremberg, Germany).