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http://reo.nii.ac.jp/journal/HtmlIndicate/Contents/SUP0000003000/JOU000300
0004/ISS0000013153/ART0000144940/ART0000144940_abstract_en.html

Carcinogenesis 24 (3) p.353-362 2003 March

Oxidative stress and ulcerative colitis-associated carcinogenesis: studies in
humans and animal models
Seril Darren N. Liao Jie Yang Guang-Yu and Yang Chung S.


Abstract
The chronic inflammatory bowel disease ulcerative colitis (UC) occurs
commonly in the US and other Western countries, but its etiology is unknown. An
association between UC and an elevated risk for colorectal cancer is well
established. UC-associated colorectal carcinogenesis is probably driven by
chronic inflammation, but the mechanism is unclear. The morphological
development of UC-associated cancer differs from that of its sporadic
counterpart. Similarly, detailed molecular ****yses have indicated that whereas
many of the genetic alterations observed in sporadic colon cancers also occur
in UC-associated neoplasms, the timing and frequency of those changes in the
setting of UC are different. These histological and molecular signatures may
very well be reflective of an inflammation-driven carcinogenesis process in UC
patients. Studies in animal models of UC have helped to shed light on the
mechanisms of inflammation-driven colorectal carcinogenesis. The available
evidence suggests that DNA damage caused by oxidative stress in the
characteristic damage–regeneration cycle is a major contributor to colorectal
cancer development in UC patients. Based on this concept, iron over-nutrition
is proposed as a risk factor and dietary antioxidants as protective factors for
UC and associated carcinogenesis.


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Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking

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http://reo.nii.ac.jp/journal/HtmlIndicate/Contents/SUP0000003000/JOU000300
0004/ISS0000013153/ART0000144940/ART0000144940_abstract_en.html

Carcinogenesis 24 (3) p.353-362 2003 March

Oxidative stress and ulcerative colitis-associated carcinogenesis: studies in
humans and animal models
Seril Darren N. Liao Jie Yang Guang-Yu and Yang Chung S.


Abstract
The chronic inflammatory bowel disease ulcerative colitis (UC) occurs
commonly in the US and other Western countries, but its etiology is unknown. An
association between UC and an elevated risk for colorectal cancer is well
established. UC-associated colorectal carcinogenesis is probably driven by
chronic inflammation, but the mechanism is unclear. The morphological
development of UC-associated cancer differs from that of its sporadic
counterpart. Similarly, detailed molecular ****yses have indicated that whereas
many of the genetic alterations observed in sporadic colon cancers also occur
in UC-associated neoplasms, the timing and frequency of those changes in the
setting of UC are different. These histological and molecular signatures may
very well be reflective of an inflammation-driven carcinogenesis process in UC
patients. Studies in animal models of UC have helped to shed light on the
mechanisms of inflammation-driven colorectal carcinogenesis. The available
evidence suggests that DNA damage caused by oxidative stress in the
characteristic damage–regeneration cycle is a major contributor to colorectal
cancer development in UC patients. Based on this concept, iron over-nutrition
is proposed as a risk factor and dietary antioxidants as protective factors for
UC and associated carcinogenesis.


Who loves ya.
Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking