kathleen.dickson

Klempner's finding, HLA-DQB1*-0602, The Multiple
Sclerosis/Lupus/Narcolepsy
correlate, binds heat shock proteins, and that is why the high
correlate with borrelia
exposure and ALS, or Lou Gehrig's disease, and multiple sclerosis.

Klempner did not reveal this data, although the US
public paid 4.7 million dollars for Klempner to study it.

http://www.actionlyme.com/Klempner_DQB1_0602.html

Lenny Sigal, reports in Schutzer's 1992 book, from a Cold
Spring Harbor Lab Conference, that the anti-heat shock
protein affect of antiflagellin may be responsible for
neurologic effects, and cytokines may be responsible for
the fatigue and sleep disorder (Fibromyalgia, Chronic
Fatigue Syndrome).


These specific biomarkers of illness are never looked for
in a typical intake assessment of a patient complaining of
Chronic fatigue, because.... Objective biomarkers of
illness might be found.

Klempner, 2001 July, South County Diseases of Summer Conference (RI-
where there is an epidemic of Fibromyalgia, thanks to Lenny Sigal,
Allen
Steere, and Phil Molloy (Imugen), AKA, Kaiser and other HMOs, etc....)


"Um, some people will view this as bad news, some will view it as good
news, and some people will say, well, where do we
go from here?� I think that really is the question, really is to
coalesce and say, �where do we go from here?

Um, There, these patients obviously, are very, very much interested in
that question, as we are, and I just want to
highlight a preliminary piece of data of where we think we’re going
from here, unpublished*, and not for large, uh,
dissemination, but here is the preliminary data.


And, that is, that when you look for the possibility of an autoimmune
disease, the best way to look is to see if there is
any genetic clustering in HLA haplotypes. The reason for that is the
way antigens get presented in the context of who you
are, that is, your HLA haplotype. And we can talk in some detail
about that. Those diseases that I think everybody would
agree are so called Autoimmune :lupus, rheumatoid arthritis, type 1
diabetes, and perhaps MS, have some clear genetic
clustering that leads us to believe that these are indeed autoimmune
diseases, although we do not satisfy so-called


particular HLA type, in the case of R.A, a DR4, or a DQB0602 to
protect you from type 1 diabetes, are on the order of 3
to 6. One of the ones that is probably highest, of course, is B27,
in patients with alkyloiding spondolytis and the
like. It turns out that if you look at the first 51 patients with
post-treatment chronic Lyme disease, the patient
population that participated in our study, there was a very high
incidence of DQB0602 with an odds ratio of 770%. So it
may well be that exposure to THAT organism with THAT background of HLA
haplotype may lead you to develop chronic symptoms.
That is a hypothesis that needs to be tested. It would obviously lead
to an entirely new form and approach to therapy."

Lenny on Heat Shock Proteins:

iochim Biophys Acta. 1993 Mar 24;1181(1):97-100. Related
Articles, Links

Molecular mimicry in Lyme disease: monoclonal antibody H9724 to B.
burgdorferi flagellin specifically detects
chaperonin-HSP60.

Dai Z, Lackland H, Stein S, Li Q, Radziewicz R, Williams S, Sigal
LH.

Center for Advanced Biotechnology and Medicine, Piscataway, NJ.

A monoclonal antibody (H9724), specific for the 41-kDa flagellar
protein of the Lyme disease pathogen Borrelia
burgdorferi, cross-reacts with human axons and detects one major
protein in human neuroblastoma cell extracts. The
homologous cross-reacting protein has now been isolated from calf
adrenal and identified as chaperonin-HSP60 by N-terminal
sequencing.

PMID: 8096152 [PubMed - indexed for MEDLINE]

ell Mol Neurobiol. 2001 Oct;21(5):477-95. Related Articles,
Links

H9724, a monoclonal antibody to Borrelia burgdorferi's flagellin,
binds to heat shock protein 60 (HSP60) within live
neuroblastoma cells: a potential role for HSP60 in peptide hormone
signaling and in an autoimmune pathogenesis of the
neuropathy of Lyme disease.

Sigal LH, Williams S, Soltys B, Gupta R.

Department of Medicine, Robert Wood Johnson Medical School.
University of Medicine and Dentistry of New Jersey, USA.
sigallh@umdnj.edu

Although Borrelia burgdorferi, the causative agent of Lyme
disease, is found at the site of many disease
manifestations, local infection may not explain all its features. B.
burgdorferi's flagellin cross-reacts with a component
of human peripheral nerve axon, previously identified as heat shock
protein 60 (HSP60). The cross-reacting epitopes are
bound by a monoclonal antibody to B. burgdorferi's flagellin, H9724.
Addition of H9724 to neuroblastoma cell cultures
blocks in vitro spontaneous and peptide growth-factor-stimulated
neuritogenesis. Withdrawal of H9724 allows return to
normal growth and differentiation. Using electron microscopy,
immunoprecipitation and immunoblotting, and FACS analysis we
sought to identify the site of binding of H9724, with the starting
hypotheses that the binding was intracellular and not
identical to the binding site of II-13, a monoclonal anti-HSP60
antibody. The current studies show that H9724 binds to an
intracellular target in cultured cells with negligible, if any,
surface binding. We previously showed that sera from
patients with neurological manifestations of Lyme disease bound to
human axons in a pattern identical to H9724's binding;
these same sera also bind to an intracellular neuroblastoma cell
target. II-13 binds to a different HSP60 epitope than
H9724: II-13 does not modify cellular function in vitro. As predicted,
II-13 bound to mitochondria, in a pattern of
cellular binding very different from H9724, which bound in a scattered
cytoplasmic, nonorganelle-related pattern. H9724's
effect is the first evidence that HSP60 may play a role in
peptide-hormone-receptor function and demonstrates the
modulatory potential of a monoclonal antibody on living cells.

PMID: 11860186 [PubMed - indexed for MEDLINE]

So, that's *2* different antibodies that bind nerve tissue,
and there are others, such as antiganglioside antibodies.
Infect Immun. 1995 Oct;63(10):4130-7. Related Articles, Links

Experimental immunization with Borrelia burgdorferi induces
development of antibodies to gangliosides.

Garcia-Monco JC, Seidman RJ, Benach JL.

Department of Neurology, Hospital de Galdacano, Vizcaya, Spain.

Patients with neuroborreliosis produce antibodies, mostly of the
immunoglobulin M (IgM) class, to gangliosides,
particularly to those with Gal(beta 1-3)GalNac terminal sequences.
Lewis rats were immunized with a nonpathogenic strain
of Borrelia burgdorferi and with a chloroform-methanol extract
(nonprotein) of this organism (CM) to determine whether
antibodies to B. burgdorferi also recognized gangliosides. Rats were
also immunized with asialo-GM1 to determine whether
the elicited antibodies recognized antigens in B. burgdorferi. Rats
immunized with B. burgdorferi produced low levels of
IgM antibodies that cross-reacted with asialo-GM1 and GM1. Rats
immunized with CM had marked IgM reactivity to asialo-GM1
and GM1. Immunization with asialo-GM1 resulted in antibodies that
cross-reacted with B. burgdorferi antigens. Although
antibodies to B. burgdorferi were of both the IgM and IgG classes,
those to CM and to asialo-GM1 and GM1 were
predominantly in the IgM fraction. Reactivity of the IgM antibodies
decreased after adsorption with the heterologous and
the homologous antigens, indicating bidirectional cross-reactivity
between CM, asialo-GM1, and GM1 and that immunization
with one produces antibodies to the other. There was no in vivo
deposition of Ig in peripheral nerves, nor was there nerve
pathology as a result of immunizations, but IgM antibodies to
asialo-GM1 and CM recognized homologous antigens in the
nodes of Ranvier of peripheral nerves from nonimmunized rats. This
immunization model suggests that antibodies to
gangliosides in Lyme disease have a microbial origin and are
potentially relevant in pathogenesis.

PMID: 7558329 [PubMed - indexed for MEDLINE]


Read it for yourself. It is available full text.

Roland Martin of the NIH (formerly of Germany), found the
other MS haplotype in borreliosis patients.
http://www.actionlyme.com/Roland%20Martin,%20NINDS.htm

That would be, uh, a Neuropsychiatric illness.

And therefore Psychological Evals are invalid. Kathleen
kathleen.dickson@snet.net (Kathleen) wrote in message news:<f46dbd96.0312181550.6a6cf6a2@posting.google. com>...

kathleen.dickson

http://www.ctnow.com/news/custom/new...dlines-newsat3
Rowland Partner Got Contracts
Paving Contractor Received $900,000 In State Work After Land Deal With
Governor
ADVERTISERS

By DAVE ALTIMARI, JON LENDER And BILL LEUKHARDT
Courant Staff Writers

December 19 2003

Gov. John G. Rowland was involved in the late 1990s in a lucrative
investment partnership that included a contractor who got more than
$900,000 in state contracts after going into business with the
governor.

Rowland's partners were Anthony R. Cocchiola, the owner of Cocchiola
Paving of Watertown; Michael H. Cicchetti, a politically connected
Waterbury lawyer whose specialties include real estate development;
and Robert Capanna, a now-deceased businessman and landowner in the
Prospect area where the partnership operated. In a statement released
Thursday in response to reporters' questions, Rowland described the
three men as friends.

The statement did not address the question of what Rowland contributed
to the partnership, in terms of time or expertise, and his office
refused to elaborate. The statement said Rowland put up about $7,200
in seed money - compared with about $10,000 each from Cocchiola and
Cicchetti and about $11,000 from Capanna. The partners shared the
profits equally, each receiving about $60,000 before the partnership,
formed in 1996, was dissolved in 2001.

In the past year Rowland has been criticized for taking discount
vacations, gifts and free home improvements to his summer cottage from
state employees and contractors who do business with the state. Other
contractors who did work on the cottage weren't paid for years,
Rowland disclosed earlier this month. Cocchiola was one of them.

Cocchiola's company got more than $345,000 in contracts from the state
while he was in business with the governor. Since the partnership,
First Development Group LLC, was dissolved, he received about $560,000
more in state work. In all, the company has done $1.3 million in state
work since Rowland took office early in 1995.

State ethics laws state that no public official "shall accept other
employment which will ... impair his independence of judgment as to
his official duties or employment."

Asked whether this could qualify as such "other employment" that could
impair the governor's judgment about paving contracts awarded by a
department of his administration, the State Ethics Commission's staff
declined to comment, saying it did not have enough information about
the case.

For his part, Rowland said in his statement, "I had nothing whatsoever
to do with that company obtaining any of those contracts."

Cocchiola's company also did $2,000 worth of work at Rowland's
Litchfield cottage in October 1997. Rowland didn't pay him for the job
until this September, when questions about work done at the cottage
started circulating in political and law enforcement circles. Earlier
this month, Rowland issued a statement saying none of the contractors
and state employees who worked on his cottage received any benefit.

Cicchetti also has ties to the Litchfield cottage: He represented
Rowland and his wife when they acquired the property, and he handled
some payments from the Rowlands to contractors.

Neither Cocchiola nor Cicchetti returned repeated calls to their
offices this week.

The work done at the cottage has come under federal scrutiny as part
of a long-running investigation into allegations of bid-rigging in
Rowland's administration. One of his former top aides has pleaded
guilty to charges of steering contracts to a contractor identified by
sources as The Tomasso Group of New Britain; a Tomasso executive,
William Tomasso, arranged for and supervised work at the cottage,
according to sources.

First Development Group's only completed project appears to be the
subdivision of a 14.4-acre parcel on the Naugatuck/Prospect town line
into 24 lots. The partnership bought the land for less than $150,000
and then sold the lots for between $37,000 and $50,000 each, according
to land records in the two towns.

None of the public documents reviewed by The Courant indicates what,
if anything, Rowland did as a member of the partnership. His name was
typed with those of his partners on two loan agreements filed in town
records in December 1997; in both cases the other three partners
signed the documents but the space above Rowland's name is blank.

Those two loans total about $357,000. Rowland's statement said the
partnership received a total of $500,000 in loans, and that each
partner signed all loan documents.

Rowland's name does not appear on any other documents related to the
partnership, and there is no record of his having attended any of the
meetings with various town officials.

Rowland listed his involvement in the partnership on his Ethics
Commission filings between 1996 and 2001, state records show. On that
form he has to indicate only that his profits were more than $1,000.
The statement does not list the names of any of his partners, or even
the address of the First Development Group, which was Cicchetti's
office.

First Development Group was incorporated in February 1996. In June of
that year the corporation purchased the 14.4-acre parcel off Clark
Hill Road in Naugatuck from the Worldwide Church of God, based in
Pasadena, Calif., for $149,500, according to town records in Naugatuck
and Prospect.

Most of the land was in Naugatuck, but a small piece was in Prospect,
requiring them to file documents in both towns.

The church's assistant secretary, Earle G. Reese, said this week he
didn't remember the land sale, even though he signed the documents.
Reese said the church often gets land left to them in wills.

"We receive property all of the time and we normally proceed to sell
it and get the best deal we can, usually through an attorney in that
area," Reese said. He did not know who the church may have hired to
help sell the Naugatuck property.

The corporation submitted a subdivision application in August 1996.
The new subdivision - Clark Hill Estates - would have 24 lots,
according to its zoning application. Most of the 21 houses would be
built in Naugatuck.

The commission approved the plan a few months later, after the staff
made recommendations to improve traffic and to offer pedestrians and
bicyclists access to the property.

The first lot was sold for $37,500 in January 1998. A review of the
warranty deeds shows the highest price for a lot was $50,000.

The lots sold over the next two years, records show. Capanna signed
for the corporation on most of the warranty deeds, and Cocchiola and
Cicchetti signed a few. Rowland's name does not appear on any of the
deeds.

Many of the lots were quit-claimed to a company called RCM Builders
LLC, of which Cicchetti also was involved, according to state records.
It's unclear if any of the others in First Development also were in
RCM Builders.

Rowland has come under heavy criticism for lying about renovations
done on his Litchfield cottage. After insisting that he had paid for
all the renovations, the governor last week admitted several people
paid for improvements to the cottage and that some contractors weren't
paid for years.

He also admitted that two figures at the center of the ongoing federal
probe, his former staffers Lawrence Alibozek and Peter Ellef, were
involved in the cottage renovations as well as Tomasso workers.

Federal authorities have interviewed some of the contractors who
worked on the cottage and subpoenaed at least one of the governor's
closest associates since The Courant broke the story about the cottage
renovations late last month.

Along with his admissions, the governor released numerous documents
listing which contractors worked at the cottage and when or if they
were paid.

One of those contractors was Cocchiola Paving Inc. of Oakville, owned
by Anthony R. Cocchiola. The company submitted its $2,000 bill to
Cicchetti on October 1997 but wasn't paid by Rowland until this
September.

Copyright 2003, Hartford Courant

kathleen.dickson

http://www.ctnow.com/news/custom/new...dlines-newsat3
Simmons To Rowland: `We Need To Know Everything'
ADVERTISERS

By CHRISTOPHER KEATING
And DAVID LIGHTMAN Courant Staff Writers

December 19 2003

Gov. John G. Rowland and U.S. Rep. Rob Simmons, two of the state's
most influential Republicans, have had a frosty relationship for years
- and it just got worse.

Some high-ranking state Democrats are not happy with first lady
Patricia Rowland's poetry, either.

Incensed about Simmons' private questioning of his misstatements about
renovations at his Bantam Lake vacation cottage, the governor hung up
on the congressman during a telephone conversation Sunday, sources
said Thursday.

The two colleagues spoke on the telephone for about 20 minutes Sunday
night as part of Rowland's decision to speak to the state's
congressional Republicans regarding his admission that several state
employees and a politically connected contractor paid for or performed
work at the 1,200-square-foot cottage in Litchfield.

"It was a very tense conversation," one source said. "Rowland did not
appreciate the comments.'" Simmons told Rowland he had "gone too far,
and we need to know everything, we need to know more," the source
said.

The conversation ended abruptly. Rowland made a point, then hung up.

"In Rob's mind, the governor did hang up on him," the source said. "He
didn't give Rob a chance to say goodbye."

Several days after Rowland hung up, Simmons issued a blistering
statement that did not defend Rowland and also raised a series of
issues that the governor had not been asked about.

Simmons acknowledged that he has agreed with Rowland on a vast array
of issues, ranging from tax cuts and creating jobs to preserving open
space and revitalizing Connecticut's cities.

"But the issue before us does not involve policies; it involves the
personal integrity of the governor and his capacity to lead and
govern," Simmons said.

"Deceptive comments regarding the Bantam Lake cottage and the
remaining ethical and legal questions concerning dubious contracting
practices, guilty pleas and firings of high-level administration
officials, discounted vacations to the homes of state contractors,
refusal to release travel documents, the federal investigation into
contract bid-rigging and the CRRA-Enron-Kenneth Lay scandal show a
disturbing pattern of lapses, omissions and lack of candor which can
no longer be ignored," the congressman said.

Simmons told Rowland that he needed to disclose everything and release
all the details for the public to see.

Simmons and Rowland have had a frosty relationship since Simmons was a
state legislator in Hartford.

He was one of three state House Republicans to vote against funding
for a new football stadium for the New England Patriots, which was
Rowland's highest priority at the time. When Simmons voted against the
stadium, Rowland never forgave him, a source said. The relationship
has deteriorated to the point of Rowland snubbing Simmons repeatedly.
When Rowland was in Simmons' district in eastern Connecticut recently,
for example, the governor failed to recognize Simmons in the audience.

Reached Thursday night on his cell phone, Simmons said, "I have no
comment about the conversation I had with the governor on Sunday
night. It was between the governor and myself. It was not for the
record. I have declined to be interviewed by the television networks."

As for his relationship with Rowland, Simmons said, "I've always
admired him for being a brilliant political person who accomplished
great things at a young age." Simmons said he supported Rowland as far
back as 1990 when Rowland ran in his first race for governor against
Lowell P. Weicker Jr.

Simmons is among a growing chorus of Republicans who are raising
questions about Rowland. Under growing pressure from Democrats to
resign, Rowland has been getting only tepid support from Republicans.
One prominent Republican said Rowland's support among the GOP faithful
is "a mile wide and an inch deep" and could diminish further if the
cottage crisis deepens.

Elsewhere Thursday, legislators continued to criticize Rowland and his
wife, Patty, for the satirical poem she read at a chamber of commerce
breakfast in Cromwell. In her own rendition of "'Twas the Night Before
Christmas," Patty Rowland ripped into the press for exposing the
ongoing scandals in the administration.

"Gov. Rowland, his family and his political handlers need to stop
campaigning and attacking at a time when the people of our state
deserve better," said Senate President Pro Tem Kevin Sullivan of West
Hartford, the highest-ranking senator. "This is not a time for
partisan political spin, speeches or inappropriate attempts to make
light of the seriousness of what has been done. It only makes it seem
that they still don't get it."

Rowland's staff apparently was caught off guard by Patty Rowland's
caustic poem, which came after Rowland delivered a speech to nearly
1,000 people that asked for forgiveness for his mistakes.

Rowland himself was pleased by his wife's poem - breaking into a huge
smile and giving her a hug after she stepped away from the podium at a
hotel ballroom.

Rowland's views became apparent in spontaneous comments that he made
that were picked up on some microphones but could not be heard
throughout the ballroom. Those comments were made after Patty Rowland
delivered a line that got the most laughter from the crowd filled with
business executives and insiders.

In her poem, Patty Rowland said, "I am late," said Santa. "My last
stop took hours - all that coal I delivered down The Courant's tall
towers."

Patty Rowland paused as the crowd laughed, and she turned to her right
to look at her husband, who was sitting nearby.

"Go for it, hon," Rowland said to his wife. "What can they do to us?"

Before continuing with her poem, Patty Rowland responded, "Yeah, it
can't get worse."

Copyright 2003, Hartford Courant

kathleen.dickson

Klempner's finding, HLA-DQB1*-0602, The Multiple
Sclerosis/Lupus/Narcolepsy
correlate, binds heat shock proteins, and that is why the high
correlate with borrelia
exposure and ALS, or Lou Gehrig's disease, and multiple sclerosis.

Klempner did not reveal this data, although the US
public paid 4.7 million dollars for Klempner to study it.

http://www.actionlyme.com/Klempner_DQB1_0602.html

Lenny Sigal, reports in Schutzer's 1992 book, from a Cold
Spring Harbor Lab Conference, that the anti-heat shock
protein affect of antiflagellin may be responsible for
neurologic effects, and cytokines may be responsible for
the fatigue and sleep disorder (Fibromyalgia, Chronic
Fatigue Syndrome).


These specific biomarkers of illness are never looked for
in a typical intake assessment of a patient complaining of
Chronic fatigue, because.... Objective biomarkers of
illness might be found.

Klempner, 2001 July, South County Diseases of Summer Conference (RI-
where there is an epidemic of Fibromyalgia, thanks to Lenny Sigal,
Allen
Steere, and Phil Molloy (Imugen), AKA, Kaiser and other HMOs, etc....)


"Um, some people will view this as bad news, some will view it as good
news, and some people will say, well, where do we
go from here?� I think that really is the question, really is to
coalesce and say, �where do we go from here?

Um, There, these patients obviously, are very, very much interested in
that question, as we are, and I just want to
highlight a preliminary piece of data of where we think we’re going
from here, unpublished*, and not for large, uh,
dissemination, but here is the preliminary data.


And, that is, that when you look for the possibility of an autoimmune
disease, the best way to look is to see if there is
any genetic clustering in HLA haplotypes. The reason for that is the
way antigens get presented in the context of who you
are, that is, your HLA haplotype. And we can talk in some detail
about that. Those diseases that I think everybody would
agree are so called Autoimmune :lupus, rheumatoid arthritis, type 1
diabetes, and perhaps MS, have some clear genetic
clustering that leads us to believe that these are indeed autoimmune
diseases, although we do not satisfy so-called


particular HLA type, in the case of R.A, a DR4, or a DQB0602 to
protect you from type 1 diabetes, are on the order of 3
to 6. One of the ones that is probably highest, of course, is B27,
in patients with alkyloiding spondolytis and the
like. It turns out that if you look at the first 51 patients with
post-treatment chronic Lyme disease, the patient
population that participated in our study, there was a very high
incidence of DQB0602 with an odds ratio of 770%. So it
may well be that exposure to THAT organism with THAT background of HLA
haplotype may lead you to develop chronic symptoms.
That is a hypothesis that needs to be tested. It would obviously lead
to an entirely new form and approach to therapy."

Lenny on Heat Shock Proteins:

iochim Biophys Acta. 1993 Mar 24;1181(1):97-100. Related
Articles, Links

Molecular mimicry in Lyme disease: monoclonal antibody H9724 to B.
burgdorferi flagellin specifically detects
chaperonin-HSP60.

Dai Z, Lackland H, Stein S, Li Q, Radziewicz R, Williams S, Sigal
LH.

Center for Advanced Biotechnology and Medicine, Piscataway, NJ.

A monoclonal antibody (H9724), specific for the 41-kDa flagellar
protein of the Lyme disease pathogen Borrelia
burgdorferi, cross-reacts with human axons and detects one major
protein in human neuroblastoma cell extracts. The
homologous cross-reacting protein has now been isolated from calf
adrenal and identified as chaperonin-HSP60 by N-terminal
sequencing.

PMID: 8096152 [PubMed - indexed for MEDLINE]

ell Mol Neurobiol. 2001 Oct;21(5):477-95. Related Articles,
Links

H9724, a monoclonal antibody to Borrelia burgdorferi's flagellin,
binds to heat shock protein 60 (HSP60) within live
neuroblastoma cells: a potential role for HSP60 in peptide hormone
signaling and in an autoimmune pathogenesis of the
neuropathy of Lyme disease.

Sigal LH, Williams S, Soltys B, Gupta R.

Department of Medicine, Robert Wood Johnson Medical School.
University of Medicine and Dentistry of New Jersey, USA.
sigallh@umdnj.edu

Although Borrelia burgdorferi, the causative agent of Lyme
disease, is found at the site of many disease
manifestations, local infection may not explain all its features. B.
burgdorferi's flagellin cross-reacts with a component
of human peripheral nerve axon, previously identified as heat shock
protein 60 (HSP60). The cross-reacting epitopes are
bound by a monoclonal antibody to B. burgdorferi's flagellin, H9724.
Addition of H9724 to neuroblastoma cell cultures
blocks in vitro spontaneous and peptide growth-factor-stimulated
neuritogenesis. Withdrawal of H9724 allows return to
normal growth and differentiation. Using electron microscopy,
immunoprecipitation and immunoblotting, and FACS analysis we
sought to identify the site of binding of H9724, with the starting
hypotheses that the binding was intracellular and not
identical to the binding site of II-13, a monoclonal anti-HSP60
antibody. The current studies show that H9724 binds to an
intracellular target in cultured cells with negligible, if any,
surface binding. We previously showed that sera from
patients with neurological manifestations of Lyme disease bound to
human axons in a pattern identical to H9724's binding;
these same sera also bind to an intracellular neuroblastoma cell
target. II-13 binds to a different HSP60 epitope than
H9724: II-13 does not modify cellular function in vitro. As predicted,
II-13 bound to mitochondria, in a pattern of
cellular binding very different from H9724, which bound in a scattered
cytoplasmic, nonorganelle-related pattern. H9724's
effect is the first evidence that HSP60 may play a role in
peptide-hormone-receptor function and demonstrates the
modulatory potential of a monoclonal antibody on living cells.

PMID: 11860186 [PubMed - indexed for MEDLINE]

So, that's *2* different antibodies that bind nerve tissue,
and there are others, such as antiganglioside antibodies.
Infect Immun. 1995 Oct;63(10):4130-7. Related Articles, Links

Experimental immunization with Borrelia burgdorferi induces
development of antibodies to gangliosides.

Garcia-Monco JC, Seidman RJ, Benach JL.

Department of Neurology, Hospital de Galdacano, Vizcaya, Spain.

Patients with neuroborreliosis produce antibodies, mostly of the
immunoglobulin M (IgM) class, to gangliosides,
particularly to those with Gal(beta 1-3)GalNac terminal sequences.
Lewis rats were immunized with a nonpathogenic strain
of Borrelia burgdorferi and with a chloroform-methanol extract
(nonprotein) of this organism (CM) to determine whether
antibodies to B. burgdorferi also recognized gangliosides. Rats were
also immunized with asialo-GM1 to determine whether
the elicited antibodies recognized antigens in B. burgdorferi. Rats
immunized with B. burgdorferi produced low levels of
IgM antibodies that cross-reacted with asialo-GM1 and GM1. Rats
immunized with CM had marked IgM reactivity to asialo-GM1
and GM1. Immunization with asialo-GM1 resulted in antibodies that
cross-reacted with B. burgdorferi antigens. Although
antibodies to B. burgdorferi were of both the IgM and IgG classes,
those to CM and to asialo-GM1 and GM1 were
predominantly in the IgM fraction. Reactivity of the IgM antibodies
decreased after adsorption with the heterologous and
the homologous antigens, indicating bidirectional cross-reactivity
between CM, asialo-GM1, and GM1 and that immunization
with one produces antibodies to the other. There was no in vivo
deposition of Ig in peripheral nerves, nor was there nerve
pathology as a result of immunizations, but IgM antibodies to
asialo-GM1 and CM recognized homologous antigens in the
nodes of Ranvier of peripheral nerves from nonimmunized rats. This
immunization model suggests that antibodies to
gangliosides in Lyme disease have a microbial origin and are
potentially relevant in pathogenesis.

PMID: 7558329 [PubMed - indexed for MEDLINE]


Read it for yourself. It is available full text.

Roland Martin of the NIH (formerly of Germany), found the
other MS haplotype in borreliosis patients.
http://www.actionlyme.com/Roland%20Martin,%20NINDS.htm

That would be, uh, a Neuropsychiatric illness.

And therefore Psychological Evals are invalid. Kathleen
kathleen.dickson@snet.net (Kathleen) wrote in message news:<f46dbd96.0312181550.6a6cf6a2@posting.google. com>...

kathleen.dickson

http://www.ctnow.com/news/custom/new...dlines-newsat3
Rowland Partner Got Contracts
Paving Contractor Received $900,000 In State Work After Land Deal With
Governor
ADVERTISERS

By DAVE ALTIMARI, JON LENDER And BILL LEUKHARDT
Courant Staff Writers

December 19 2003

Gov. John G. Rowland was involved in the late 1990s in a lucrative
investment partnership that included a contractor who got more than
$900,000 in state contracts after going into business with the
governor.

Rowland's partners were Anthony R. Cocchiola, the owner of Cocchiola
Paving of Watertown; Michael H. Cicchetti, a politically connected
Waterbury lawyer whose specialties include real estate development;
and Robert Capanna, a now-deceased businessman and landowner in the
Prospect area where the partnership operated. In a statement released
Thursday in response to reporters' questions, Rowland described the
three men as friends.

The statement did not address the question of what Rowland contributed
to the partnership, in terms of time or expertise, and his office
refused to elaborate. The statement said Rowland put up about $7,200
in seed money - compared with about $10,000 each from Cocchiola and
Cicchetti and about $11,000 from Capanna. The partners shared the
profits equally, each receiving about $60,000 before the partnership,
formed in 1996, was dissolved in 2001.

In the past year Rowland has been criticized for taking discount
vacations, gifts and free home improvements to his summer cottage from
state employees and contractors who do business with the state. Other
contractors who did work on the cottage weren't paid for years,
Rowland disclosed earlier this month. Cocchiola was one of them.

Cocchiola's company got more than $345,000 in contracts from the state
while he was in business with the governor. Since the partnership,
First Development Group LLC, was dissolved, he received about $560,000
more in state work. In all, the company has done $1.3 million in state
work since Rowland took office early in 1995.

State ethics laws state that no public official "shall accept other
employment which will ... impair his independence of judgment as to
his official duties or employment."

Asked whether this could qualify as such "other employment" that could
impair the governor's judgment about paving contracts awarded by a
department of his administration, the State Ethics Commission's staff
declined to comment, saying it did not have enough information about
the case.

For his part, Rowland said in his statement, "I had nothing whatsoever
to do with that company obtaining any of those contracts."

Cocchiola's company also did $2,000 worth of work at Rowland's
Litchfield cottage in October 1997. Rowland didn't pay him for the job
until this September, when questions about work done at the cottage
started circulating in political and law enforcement circles. Earlier
this month, Rowland issued a statement saying none of the contractors
and state employees who worked on his cottage received any benefit.

Cicchetti also has ties to the Litchfield cottage: He represented
Rowland and his wife when they acquired the property, and he handled
some payments from the Rowlands to contractors.

Neither Cocchiola nor Cicchetti returned repeated calls to their
offices this week.

The work done at the cottage has come under federal scrutiny as part
of a long-running investigation into allegations of bid-rigging in
Rowland's administration. One of his former top aides has pleaded
guilty to charges of steering contracts to a contractor identified by
sources as The Tomasso Group of New Britain; a Tomasso executive,
William Tomasso, arranged for and supervised work at the cottage,
according to sources.

First Development Group's only completed project appears to be the
subdivision of a 14.4-acre parcel on the Naugatuck/Prospect town line
into 24 lots. The partnership bought the land for less than $150,000
and then sold the lots for between $37,000 and $50,000 each, according
to land records in the two towns.

None of the public documents reviewed by The Courant indicates what,
if anything, Rowland did as a member of the partnership. His name was
typed with those of his partners on two loan agreements filed in town
records in December 1997; in both cases the other three partners
signed the documents but the space above Rowland's name is blank.

Those two loans total about $357,000. Rowland's statement said the
partnership received a total of $500,000 in loans, and that each
partner signed all loan documents.

Rowland's name does not appear on any other documents related to the
partnership, and there is no record of his having attended any of the
meetings with various town officials.

Rowland listed his involvement in the partnership on his Ethics
Commission filings between 1996 and 2001, state records show. On that
form he has to indicate only that his profits were more than $1,000.
The statement does not list the names of any of his partners, or even
the address of the First Development Group, which was Cicchetti's
office.

First Development Group was incorporated in February 1996. In June of
that year the corporation purchased the 14.4-acre parcel off Clark
Hill Road in Naugatuck from the Worldwide Church of God, based in
Pasadena, Calif., for $149,500, according to town records in Naugatuck
and Prospect.

Most of the land was in Naugatuck, but a small piece was in Prospect,
requiring them to file documents in both towns.

The church's assistant secretary, Earle G. Reese, said this week he
didn't remember the land sale, even though he signed the documents.
Reese said the church often gets land left to them in wills.

"We receive property all of the time and we normally proceed to sell
it and get the best deal we can, usually through an attorney in that
area," Reese said. He did not know who the church may have hired to
help sell the Naugatuck property.

The corporation submitted a subdivision application in August 1996.
The new subdivision - Clark Hill Estates - would have 24 lots,
according to its zoning application. Most of the 21 houses would be
built in Naugatuck.

The commission approved the plan a few months later, after the staff
made recommendations to improve traffic and to offer pedestrians and
bicyclists access to the property.

The first lot was sold for $37,500 in January 1998. A review of the
warranty deeds shows the highest price for a lot was $50,000.

The lots sold over the next two years, records show. Capanna signed
for the corporation on most of the warranty deeds, and Cocchiola and
Cicchetti signed a few. Rowland's name does not appear on any of the
deeds.

Many of the lots were quit-claimed to a company called RCM Builders
LLC, of which Cicchetti also was involved, according to state records.
It's unclear if any of the others in First Development also were in
RCM Builders.

Rowland has come under heavy criticism for lying about renovations
done on his Litchfield cottage. After insisting that he had paid for
all the renovations, the governor last week admitted several people
paid for improvements to the cottage and that some contractors weren't
paid for years.

He also admitted that two figures at the center of the ongoing federal
probe, his former staffers Lawrence Alibozek and Peter Ellef, were
involved in the cottage renovations as well as Tomasso workers.

Federal authorities have interviewed some of the contractors who
worked on the cottage and subpoenaed at least one of the governor's
closest associates since The Courant broke the story about the cottage
renovations late last month.

Along with his admissions, the governor released numerous documents
listing which contractors worked at the cottage and when or if they
were paid.

One of those contractors was Cocchiola Paving Inc. of Oakville, owned
by Anthony R. Cocchiola. The company submitted its $2,000 bill to
Cicchetti on October 1997 but wasn't paid by Rowland until this
September.

Copyright 2003, Hartford Courant

kathleen.dickson

http://www.ctnow.com/news/custom/new...dlines-newsat3
Simmons To Rowland: `We Need To Know Everything'
ADVERTISERS

By CHRISTOPHER KEATING
And DAVID LIGHTMAN Courant Staff Writers

December 19 2003

Gov. John G. Rowland and U.S. Rep. Rob Simmons, two of the state's
most influential Republicans, have had a frosty relationship for years
- and it just got worse.

Some high-ranking state Democrats are not happy with first lady
Patricia Rowland's poetry, either.

Incensed about Simmons' private questioning of his misstatements about
renovations at his Bantam Lake vacation cottage, the governor hung up
on the congressman during a telephone conversation Sunday, sources
said Thursday.

The two colleagues spoke on the telephone for about 20 minutes Sunday
night as part of Rowland's decision to speak to the state's
congressional Republicans regarding his admission that several state
employees and a politically connected contractor paid for or performed
work at the 1,200-square-foot cottage in Litchfield.

"It was a very tense conversation," one source said. "Rowland did not
appreciate the comments.'" Simmons told Rowland he had "gone too far,
and we need to know everything, we need to know more," the source
said.

The conversation ended abruptly. Rowland made a point, then hung up.

"In Rob's mind, the governor did hang up on him," the source said. "He
didn't give Rob a chance to say goodbye."

Several days after Rowland hung up, Simmons issued a blistering
statement that did not defend Rowland and also raised a series of
issues that the governor had not been asked about.

Simmons acknowledged that he has agreed with Rowland on a vast array
of issues, ranging from tax cuts and creating jobs to preserving open
space and revitalizing Connecticut's cities.

"But the issue before us does not involve policies; it involves the
personal integrity of the governor and his capacity to lead and
govern," Simmons said.

"Deceptive comments regarding the Bantam Lake cottage and the
remaining ethical and legal questions concerning dubious contracting
practices, guilty pleas and firings of high-level administration
officials, discounted vacations to the homes of state contractors,
refusal to release travel documents, the federal investigation into
contract bid-rigging and the CRRA-Enron-Kenneth Lay scandal show a
disturbing pattern of lapses, omissions and lack of candor which can
no longer be ignored," the congressman said.

Simmons told Rowland that he needed to disclose everything and release
all the details for the public to see.

Simmons and Rowland have had a frosty relationship since Simmons was a
state legislator in Hartford.

He was one of three state House Republicans to vote against funding
for a new football stadium for the New England Patriots, which was
Rowland's highest priority at the time. When Simmons voted against the
stadium, Rowland never forgave him, a source said. The relationship
has deteriorated to the point of Rowland snubbing Simmons repeatedly.
When Rowland was in Simmons' district in eastern Connecticut recently,
for example, the governor failed to recognize Simmons in the audience.

Reached Thursday night on his cell phone, Simmons said, "I have no
comment about the conversation I had with the governor on Sunday
night. It was between the governor and myself. It was not for the
record. I have declined to be interviewed by the television networks."

As for his relationship with Rowland, Simmons said, "I've always
admired him for being a brilliant political person who accomplished
great things at a young age." Simmons said he supported Rowland as far
back as 1990 when Rowland ran in his first race for governor against
Lowell P. Weicker Jr.

Simmons is among a growing chorus of Republicans who are raising
questions about Rowland. Under growing pressure from Democrats to
resign, Rowland has been getting only tepid support from Republicans.
One prominent Republican said Rowland's support among the GOP faithful
is "a mile wide and an inch deep" and could diminish further if the
cottage crisis deepens.

Elsewhere Thursday, legislators continued to criticize Rowland and his
wife, Patty, for the satirical poem she read at a chamber of commerce
breakfast in Cromwell. In her own rendition of "'Twas the Night Before
Christmas," Patty Rowland ripped into the press for exposing the
ongoing scandals in the administration.

"Gov. Rowland, his family and his political handlers need to stop
campaigning and attacking at a time when the people of our state
deserve better," said Senate President Pro Tem Kevin Sullivan of West
Hartford, the highest-ranking senator. "This is not a time for
partisan political spin, speeches or inappropriate attempts to make
light of the seriousness of what has been done. It only makes it seem
that they still don't get it."

Rowland's staff apparently was caught off guard by Patty Rowland's
caustic poem, which came after Rowland delivered a speech to nearly
1,000 people that asked for forgiveness for his mistakes.

Rowland himself was pleased by his wife's poem - breaking into a huge
smile and giving her a hug after she stepped away from the podium at a
hotel ballroom.

Rowland's views became apparent in spontaneous comments that he made
that were picked up on some microphones but could not be heard
throughout the ballroom. Those comments were made after Patty Rowland
delivered a line that got the most laughter from the crowd filled with
business executives and insiders.

In her poem, Patty Rowland said, "I am late," said Santa. "My last
stop took hours - all that coal I delivered down The Courant's tall
towers."

Patty Rowland paused as the crowd laughed, and she turned to her right
to look at her husband, who was sitting nearby.

"Go for it, hon," Rowland said to his wife. "What can they do to us?"

Before continuing with her poem, Patty Rowland responded, "Yeah, it
can't get worse."

Copyright 2003, Hartford Courant