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1 3rd July 11:12
ironjustice
External User
 
Posts: 1
Default Life Saving Blood Thinner Warfarin (aspirin warfarin polycythemia hematocrit polycythemia vera)


It seems adding / using this popular drug .. helps.

Surprise .. surprise .. seeing that the reason FOR .. **having** to
USE the drug / blood thinners .. in the first place .. IS .. the
increased red blood cell production / erythrocytosis /
hyperviscosity .. **itself**.

Sooo .. 'they' use it .. here .. to **guarantee** the patient
doesn't .. die .. ?

Must be to make **sure** the patient is around to pay for the
operation .. ?

I wonder if they get paid if the patient .. dies .. ?

J Card Surg. 2007 Sep-Oct;22(5):420-2. Links
Anticoagulation after coronary artery surgery in patients with
polycythemia vera: report of two cases.
Oz BS, Asgun F, Akay HT, Kaya E, Kuralay E, Tatar H.
Department of Cardiovascular Surgery, Gulhane Military Medicine
School, Ankara, Turkey.

Polycythemia vera is a myeloproliferative disorder associated with the
thromboembolic events. Normalization of the hematocrit and elevated
platelet counts is obligatory to reduce the thrombotic risk of
patients with PV. The****utic strategies include phlebotomy,
myelosuppressive agents, and, more recently, interferon-alpha. In
addition, appropriate antiplatelet therapy should be administered to
prevent life-threatening complications and reducing the viscosity of
the blood. Although aspirin is widely preferred in such patients, this
monodrug therapy or combined with clopidogrel as an alternative
approach might not be enough, especially after coronary artery
surgery. Therefore, warfarin should be added to anticoagulant therapy.
This short report describes the use of warfarin, associated with
aspirin and clopidogrel as an anticoagulant regimen after coronary
artery bypass surgery in two cases with polycythemia vera. We believe
that a combination of warfarin with other oral antiplatelet agents may
be more effective in preventing the coronary artery bypass graft
thrombosis.

PMID: 17803581 [PubMed - in process]


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2 3rd July 11:12
External User
 
Posts: 1
Default Life Saving Blood Thinner Warfarin (diet)


So which is it, is thick blood or iron the cause of all disease because
people eat meat?

Jesus ate a mediterranean diet.
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3 3rd July 11:13
ironjustice
External User
 
Posts: 1
Default Life Saving Blood Thinner Warfarin


because
people eat meat? <<

Why do you want to know .. ?

You keeping .. notes .. ?

You've been told many times and you **again** ask this question ..
so .. it means you are NOT keeping .. notes ..

Sooo .. if you are not keeping notes .. and you have no ability to ..
recall .. things / stuff ..

Then why are you asking .. ?

You going to NOW .. begin .. TO .. keep notes .. ?


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Tom


Jesus Was A Vegetarian!
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4 3rd July 11:13
ironjustice
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Posts: 1
Default Life Saving Blood Thinner Warfarin (renal kidney neuropathy polycythemia hematocrit)


because
people eat meat?
<<

Prove your mettle .. earn your keep .. you tell .. US ..

I'll give you a couple of .. hints .. you seem to need all the help
you can .. get .. ?

Iron overload / hemochromatosis is CALLED erythrocytosis / one and the
same / "category of erythrocytosis".
Erythrocytosis is ALWAYS **accompanied** BY .. **hyperviscosity** /
thick blood.
Erythrocytosis / thick blood / iron overload / hemochromatosis leads
to ..

"paralysis,degenerative processes in liver and kidney,vascular
permeability, chronic progressive inflammation, hemosiderin
deposition, general vasodilatation,severe nerve fiber degeneration of
the sciatic nerve, decreased number of neuromuscular junctions, and
degeneration of skeletal muscle fibers,demyelinating
neuropathy,muscular degeneration,multiple organ degeneration,reduced
life expectancy"

Soooo .. WHAT causes the .. problems IN these animals .. ?

Is it the thick blood .. is it the iron .. is it the epo .. ?

Which .. one .. ? all of them .. ?

When you figure it out .. place the answer .. here ..
[_______________]

I won't bother to wait ..
--------------------------------------------------------------------------------

Am J Physiol Regul Integr Comp Physiol 291: R947-R956, 2006. First
published May 11, 2006; doi:10.1152/ajpregu.00152.2006

Excessive erythrocytosis in adult mice overexpressing erythropoietin
leads to hepatic, renal, neuronal, and muscular degeneration
Katja Heinicke,1,2 Oliver Baum,3 Omolara O. Ogunshola,1 Johannes Vogel,
1 Thomas Stallmach,4 David P. Wolfer,5 Stephan Keller,1 Klaus Weber,6
Peter D. Wagner,2 Max Gassmann,1 and Valentin Djonov3
1Institute of Veterinary Physiology, Vetsuisse Faculty and Zurich
Center for Integrative Human Physiology (ZIHP), 4Department of
Pathology, and 5Institute of Anatomy, University of Zurich, Zurich;
3Institute of Anatomy, University of Berne, Berne; 6RCC Ltd, Itingen,
Switzerland; and 2Division of Physiology, Department of Medicine,
University of California San Diego, La Jolla, California

Submitted 6 March 2006 ; accepted in final form 8 May 2006


To investigate the consequences of inborn excessive erythrocytosis, we
made use of our transgenic mouse line (tg6) that constitutively
overexpresses erythropoietin (Epo) in a hypoxia-independent manner,
thereby reaching hematocrit levels of up to 0.89. We detected
expression of human Epo in the brain and, to a lesser extent, in the
lung but not in the heart, kidney, or liver of tg6 mice. Although no
acute cardiovascular complications are observed, tg6 animals have a
reduced lifespan. Decreased swim performance was observed in 5-mo-old
tg6 mice. At about 7 mo, several tg6 animals developed spastic
contractions of the hindlimbs followed by paralysis. Morphological
****ysis by light and electron microscopy showed degenerative
processes in liver and kidney characterized by increased vascular
permeability, chronic progressive inflammation, hemosiderin
deposition, and general vasodilatation. Moreover, most of the animals
showed severe nerve fiber degeneration of the sciatic nerve, decreased
number of neuromuscular junctions, and degeneration of skeletal muscle
fibers. Most probably, the developing demyelinating neuropathy
resulted in muscular degeneration demonstrated in the extensor
digitorum longus muscle. Taken together, chronically increased Epo
levels inducing excessive erythrocytosis leads to multiple organ
degeneration and reduced life expectancy. This model allows
investigation of the impact of excessive erythrocytosis in individuals
suffering from polycythemia vera, chronic mountain sickness, or in
subjects tempted to abuse Epo by means of gene doping.

chronic mountain sickness; erythropoietin doping; neurodegeneration;
neuromuscular junctions; polycythemia; vascular permeability

--------------------------------------------------------------------------------

Address for reprint requests and other correspondence: V. Djonov,
Institute of Anatomy, Univ. of Berne, Baltzerstrasse 2, CH-3009 Berne
9/Switzerland (e-mail: djonov@ana.unibe.ch)


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5 3rd July 11:13
External User
 
Posts: 1
Default Life Saving Blood Thinner Warfarin


What are the two main ways the body keeps serum iron levels constant in
the body?
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6 23rd July 16:12
ironjustice
External User
 
Posts: 1
Default Life Saving Blood Thinner Warfarin (diabetes stress heart cardiovascular cancer)


in
the body?
<<

It .. doesn't ..

It is called .. age related iron **ac***ulation** ..

Plant irons are most beneficial to the body because their absorption
remains
safely regulated, whereas iron from animal sources tends to ac***ulate
to
levels which increase free radical activity contributing to heart
disease,
cancer, and the aging process.
--Presented at the National Meeting of the American Chemical Society
by
Tung-Ching Lee, a food scientist at Rutgers University in New
Brunswick, N.J.,
April 2000. reprinted from Good Medicine, PCRM, August 2000

In diabetes it is called .. free floating iron ..

RESULTS: NTBI (non-transferrin-bound iron ) was commonly present in
diabetes: 59% in newly diagnosed diabetes and 92% in advanced
diabetes

Diabetes Care. 2006 May;29(5):1090-5. Related Articles, Links


Common presence of non-transferrin-bound iron among patients with
type
2 diabetes.


Lee DH, Liu DY, Jacobs DR Jr, Shin HR, Song K, Lee IK, Kim B, Hider
RC.


Department of Preventive Medicine, School of Medicine, Kyungpook
University, 101 Dongin-dong, Jung-gu, Daegu, Korea 700-422.
lee...@knu.ac.kr.


OBJECTIVE: Recently, we reported increased cardiovascular disease
mortality among supplemental vitamin C users with type 2 diabetes in
a
prospective cohort study. Because vitamin C may cause oxidative
stress
in the presence of redox active iron, we hypothesized that
non-transferrin-bound iron (NTBI), a form of iron susceptible to
redox
activity, may be present in patients with type 2 diabetes. RESEARCH
DESIGN AND METHODS: We measured serum NTBI levels using
high-performance liquid chromatography in 48 patients with known
diabetes (at least 5 years duration since diagnosis), 49 patients
with
newly diagnosed diabetes, and 47 healthy control subjects (frequency
matched on age and ***). RESULTS: NTBI was commonly present in
diabetes: 59% in newly diagnosed diabetes and 92% in advanced
diabetes.
Mean NTBI values varied significantly between the three groups, with
the highest values being observed in patients with known diabetes and
the lowest in the control subjects (0.62 +/- 0.43 vs. 0.24 +/- 0.29
vs.
0.04 +/- 0.13 mumol/l Fe). Serum total iron or percent transferrin
saturation were very similar among the three groups, yet NTBI was
strongly associated with serum total iron (r = 0.74, P < 0.01) and
percent transferrin saturation (r = 0.70, P < 0.01) among the
patients
with known diabetes. CONCLUSIONS: Consistent with our hypothesis,
these
data demonstrate the common existence of NTBI in type 2 diabetic
patients with a strong gradient with severity. Prospective cohort
studies are required to clarify the clinical relevance of increased
NTBI levels.


PMID: 16644642 [PubMed - in process]


---------------------------------------------------------------------------*-----


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com


Man Is A Herbivore!
http://tinyurl.com/a3cc3


DEAD PEOPLE WALKING
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7 23rd July 16:12
External User
 
Posts: 1
Default Life Saving Blood Thinner Warfarin


You should know the two main ways the body regulates iron levels. A
iron "expert" pausing on his way to oslo to make a few posts in
newsgroups should know this. The article you posted was 2000, a
lifetime in such research.

Use instead an article published just this month:

Liver-gut axis in the regulation of iron homeostasis

do a medline search and report back as to what it says. Because you do
searches daily it is a strange thing you did not post that abstract
before this. We wonder why?
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8 23rd July 16:12
manky badger
External User
 
Posts: 1
Default Life Saving Blood Thinner Warfarin


Well, that's his theory stuffed then.
Cue the personal abuse, the swear words with no vowels and and the dots )
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9 23rd July 16:12
ironjustice
External User
 
Posts: 1
Default Life Saving Blood Thinner Warfarin (diabetes stress heart cardiovascular cancer)


What part of .. "it doesn't" .. don't you understand .. ?

"It .. doesn't ..


It is called .. age related iron **ac***ulation** ..


Plant irons are most beneficial to the body because their absorption
remains
safely regulated, whereas iron from animal sources tends to
ac***ulate
to
levels which increase free radical activity contributing to heart
disease,
cancer, and the aging process.
--Presented at the National Meeting of the American Chemical Society
by
Tung-Ching Lee, a food scientist at Rutgers University in New
Brunswick, N.J.,
April 2000. reprinted from Good Medicine, PCRM, August 2000


In diabetes it is called .. free floating iron ..


RESULTS: NTBI (non-transferrin-bound iron ) was commonly present in
diabetes: 59% in newly diagnosed diabetes and 92% in advanced
diabetes


Diabetes Care. 2006 May;29(5):1090-5. Related Articles, Links


Common presence of non-transferrin-bound iron among patients with
type
2 diabetes.


Lee DH, Liu DY, Jacobs DR Jr, Shin HR, Song K, Lee IK, Kim B, Hider
RC.


Department of Preventive Medicine, School of Medicine, Kyungpook
University, 101 Dongin-dong, Jung-gu, Daegu, Korea 700-422.
lee...@knu.ac.kr.


OBJECTIVE: Recently, we reported increased cardiovascular disease
mortality among supplemental vitamin C users with type 2 diabetes in
a
prospective cohort study. Because vitamin C may cause oxidative
stress
in the presence of redox active iron, we hypothesized that
non-transferrin-bound iron (NTBI), a form of iron susceptible to
redox
activity, may be present in patients with type 2 diabetes. RESEARCH
DESIGN AND METHODS: We measured serum NTBI levels using
high-performance liquid chromatography in 48 patients with known
diabetes (at least 5 years duration since diagnosis), 49 patients
with
newly diagnosed diabetes, and 47 healthy control subjects (frequency
matched on age and ***). RESULTS: NTBI was commonly present in
diabetes: 59% in newly diagnosed diabetes and 92% in advanced
diabetes.
Mean NTBI values varied significantly between the three groups, with
the highest values being observed in patients with known diabetes and
the lowest in the control subjects (0.62 +/- 0.43 vs. 0.24 +/- 0.29
vs.
0.04 +/- 0.13 mumol/l Fe). Serum total iron or percent transferrin
saturation were very similar among the three groups, yet NTBI was
strongly associated with serum total iron (r = 0.74, P < 0.01) and
percent transferrin saturation (r = 0.70, P < 0.01) among the
patients
with known diabetes. CONCLUSIONS: Consistent with our hypothesis,
these
data demonstrate the common existence of NTBI in type 2 diabetic
patients with a strong gradient with severity. Prospective cohort
studies are required to clarify the clinical relevance of increased
NTBI levels.


PMID: 16644642 [PubMed - in process]


---------------------------------------------------------------------------**-----
"


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com


Man Is A Herbivore!
http://tinyurl.com/a3cc3


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
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