ironjustice

Plasma esterified f2-isoprostanes and oxidative stress in newborns:
role of nonprotein-bound iron. [Journal Article]
Pediatr Res 2008 Mar; 63(3):287-91.
Signorini C, Perrone S, Sgherri C, Ciccoli L, Buonocore G, Leoncini S,
Rossi V, Vecchio D, Comporti M

Nonprotein-bound iron (NPBI) and F2-isoprostanes, reliable markers of
oxidative stress, are increased in plasma of newborns and inversely
correlated to the gestational age. Because NPBI represents a pro-
oxidant stimulus in plasma, we test the hypothesis that the entity of
lipid peroxidation is related with NPBI concentrations. Plasma levels
of free, esterified, and total F2-isoprostanes were investigated in
relation to NPBI levels in 59 newborns and 16 healthy adults. The pro-
oxidant role of iron was ascertained in vitro, by measuring all the
forms of F2-isoprostanes after incubation with ammonium iron sulfate.
Significant positive correlations were found between NPBI and total as
well as esterified F2-isoprostanes in plasma of the newborns. The
addition of ammonium iron sulfate induced a marked increase in all the
forms of F2-isoprostanes after 2 hours of incubation. The higher NPBI
concentration, the higher F2-isoprostanes levels. An increase NPBI
dose dependent in total F2-isoprostanes formation was observed in
dialyzed low density lipoprotein from adult plasma. The results
clearly show that once NPBI is generated, whatever its source, it is
capable of inducing oxidative stress. NPBI-induced oxidative stress
may contribute to the morbidity in preterm infants that are
particularly susceptible to free radical damage. ABBREVIATIONS::

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