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11 24th February 08:54
deon
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Posts: 1
Default Restoril aka Temazepam - Need Advice (temazepam)


Please tell us about your experiences with temazepam.
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12 24th February 18:55
jake
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Posts: 1
Default Restoril aka Temazepam - Need Advice (eye)


It worked but made me feel woozy and unable to think clearly in th
day..like ahead full of cotton wool or something..
I was cross to not even be told it was rapidly addictive..

highly desireable head change for those wanting a buzz though..
high street value..and injected..sometimes solidifying in the veins..

__

"When society turns a blind eye to the dangers of drugs and rushes to embrace a
pharmaceutical cure for nearly every condition, there is almost no end to the
harm that may result".

Thomas.J.Moore
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13 25th February 13:43
larry hoover
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Posts: 1
Default Restoril aka Temazepam - Need Advice (withdrawal)


Here we go.....pulling some atypical adverse response out the air
(references?), without any context (incidence?). As the particular adverse
event is defined as "rare" (I looked it up), and is absolutely managed by
following the instructions which would be provided with the med, focussing
on it brings us back to the historical problem I have with your
arguments......akin to "the boy who cries wolf", or perhaps to "Chicken Little".

My apologies for the ad hominem remark.

Fine. For the record, I always do research before I post. Long-term
temazepam use is not associated with tolerance or dependence in the same way
as are other benzos. My statements to the effect that I and others have
successfully used benzos for primary insomnia and other diagnosed sleep
disorders, over many years, was consistent with the medical literature, or I
would have posted a remark to that effect, along with the anecdote. I
reiterate my remarks; long-term temazepam therapy for insomnia is remarkably
safe.

Br J Clin Pharmacol. 1997 Sep;44(3):267-75. Related Articles, Links


A study of the effects of long-term use on individual sensitivity to
temazepam and lorazepam in a clinical population.

van Steveninck AL, Wallnofer AE, Schoemaker RC, Pieters MS, Danhof M, van
Gerven JM, Cohen AF.

Centre for Human Drug Research, Leiden University Hospital, The Netherlands.

AIMS: The central effects of benzodiazepines may be attenuated after chronic
use by changes in pharmacokinetics, pharmacodynamics or both. This
attenuation may be influenced by the dosing pattern and the characteristics
of the user population. The objectives of this study were to evaluate drug
sensitivity in long-term users of temazepam and lorazepam in a clinical
population. METHODS: The sensitivity to benzodiazepine effects in chronic
users (1-20 years) of lorazepam (n = 14) or temazepam (n = 13) was evaluated
in comparison with age and *** matched controls. Drug sensitivity was
evaluated by plasma concentration in relation to saccadic eye movement
parameters, postural stability and visual ****ogue scales. RESULTS:
Pharmacokinetics of lorazepam and temazepam did not differ between patients
and control subjects. Chronic users of lorazepam showed clear evidence of
reduced sensitivity, indicated by lack of any pharmacodynamic difference
between patients and controls at baseline, when drug concentrations were
similar to the peak values attained in the control subjects after
administration of 1-2.5 mg of lorazepam. In addition, there was a two- to
four fold reduction in the slopes of concentration-effect plots for measures
of saccadic eye movements and body sway (all; P < or = 0.01). By contrast,
sensitivity in chronic users of temazepam was not different from controls.
The difference between the temazepam and the lorazepam group appears to be
associated with a more continuous drug exposure in the latter, due to the
longer half-life and a more frequent intake of lorazepam. This pattern of
use may be partly related to the more anxious personality traits that were
observed in the chronic users of lorazepam. CONCLUSIONS: Chronic users of
lorazepam show evidence of tolerance to sedative effects in comparison with
healthy controls. Tolerance does not occur in chronic users of temazepam.
The difference may be related to pharmacological properties, in addition to
different patterns of use, associated with psychological factors.

Not in the least. If you go back to the original poster's message, you'll
see that she discovered the idea that temazepam therapy is limited-term via
her own research, not as the result of information from the prescribing physician.


Not "is". May be.....

There is a substantial body of evidence that different benzos have their own
unique tendency to cause dependency, and withdrawal. They should not be
painted with the same black brush.


Not addicted. There is no evidence that she felt compulsion to escalate her
dose, for example, or to use her medication in a manner or for a reason
other than that directed by the prescribing physician. What Squig had was
dependency, a physiological adaptation to the presence of the drug.

Clonazepam has a well-recognized withdrawal process, which can be horrific.
It is not unmanageable, however, given appropriate supportive measures. As I
recall, she was left to try and manage the withdrawal on her own, something
she was not adequately prepared to do.


Indeed. And that is why I restricted my own remarks to the
temazepam-treatment of insomnia, as defined by the original poster.


Just to be clear, insomnia is a fatal disorder. It is a primary contributory
factor in transportation accidents, workplace accidents, and accidents in
the home, many of which are fatal. It promotes or contributes to the
development of insulin resistance, heart disease, chronic pain syndromes,
and is strongly associated with a number of mental disorders. There is also
an association with suicide.

See:
http://my.webmd.com/content/article/21/1728_54860
http://bmj.bmjjournals.com/cgi/content/full/326/7384/302/c
http://iucar.iu.edu/center/person/mchorney/ab_18.htm
http://www.tfhrc.gov/humanfac/sleep/sleepweb.htm
http://diabetes.about.com/library/blnews/blnsleep601.htm
http://www.sleepreviewmag.com/articles.asp?articleid=S0305F01

Given the adverse health risks for the entire population of insomniacs, it
would be prudent to weigh the risks of that entire population against the
risks of treatment (offered to only a minor fraction of all insomniacs,
sadly) who may be offered temazepam as therapy (a relatively small fraction
of itself a minor fraction of the entire population of insomniacs).

Absent tolerance, let alone the other defining behaviours of addiction, you
persist in misrepresenting the use of hypnotics to treat a real disorder as
addiction. Right.

Please provide us with your opinion with respect to the use of heroin in
palliative care. Or the use of Oxycontin in the management of reflex sympathetic dystrophy.


Straw man argument.

So, let's just leave them untreated?


But we're not talking about those time-limited cases here.

Rather than quoting a single sentence out of context, I left it in its
context, to restrict any apprehension of bias on my part. I note, however,
that you snipped and ignored the only sentence that was relevant to the
present discussion.

"Relief of insomnia has been do***ented during periods of regular nightly
use for up to 6 months (35, p. 138S). "

Moreover, I do believe that it is relevant that temazepam use over many
years is safely managed, even if the referent disorder is seizure-related.


the

Rather than focussing on that single pair of words, why not consider the
meaning of the last sentence, which refers to the entire paragraph preceding
it?

There are differences between the individual members of the benzodiazepine
class.

Lar
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14 25th February 13:44
larry hoover
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Posts: 1
Default Restoril aka Temazepam - Need Advice (withdrawal)


Yes, that is a known side-effect, probably related to liver function.


*Tolerance* may develop quickly. Addiction is another concept entirely. So,
did you become tolerant to the drug? Withdrawal symptoms on discontinuation?

You're really stretching now. That's like throwing down the "race card", or
the "gender card".

The street use comes simply from availability. Addicts who use opiates via
injection develop anxiety and insomnia as part of their behaviour. Addiction
is the primary disorder, with the latter two secondary to it. Treatment for
the secondary symptoms often involves prescriptions for a benzo, with
temazepam being a favoured one, due to its half-life, and its tendency to
produce somnolence.

Temazepam does not solidify in the veins. It can, however, promote ischemia
via coagulation of the blood. It was not intended for IV administration in
the first place, so referring to this adverse effect, seen only in a
population already so ill, is quite inappropriate. Benzodiazepine dependency
in this population seems to be a trait marker for undiagnosed mood
disorders. I would argue for greater supportive care for this population,
rather than stretching the facts to discredit a particular medication. In
any case, your rationale has always eluded me.

Drug Alcohol Rev. 2003 Jun;22(2):153-7. Related Articles, Links


Association of benzodiazepine injection with the prescription of temazepam
capsules.

Dobbin M, Martyres RF, Clode D, Champion De Crespigny FE.

Melbourne Division of General Practice, Parkville, Victoria, Australia.

Temazepam capsules have become a popular choice for benzodiazepine injection
by injecting drug users, and serious vascular and tissue damage leading to
ulcers and gangrene can result. We compared the self-reported benzodiazepine
injecting behaviour of 91 heroin users with their Pharmaceutical Benefits
Schedule (PBS) records for the preceding 5 years. We found that individuals
prescribed PBS temazepam capsules were more likely to report injecting
benzodiazepines than individuals who had either not been prescribed PBS
temazepam capsules or had been prescribed PBS temazepam tablets. These
results provide empirical support for the argument to limit the prescription
and supply of temazepam capsules in Australia.

Addiction. 1997 Jun;92(6):697-705. Related Articles, Links


Transitions between routes of benzodiazepine administration among heroin
users in Sydney.

Ross J, Darke S, Hall W.

National Drug and Alcohol Research Centre, University of New South Wales,
Australia.

A sample of 312 heroin users were interviewed regarding their benzodiazepine
use. The majority (94%) had used benzodiazepines, 72% in the 6 months prior
to interview. Benzodiazepine injecting was common, with 28% of the sample
having injected these drugs, 13% in the 6 months preceding interview.
Current benzodiazepine injectors showed greater polydrug use,
injection-related HIV risk-taking behaviour, criminal involvement,
psychological distress and injection-related health problems, as well as
poorer general health, and an increased risk of having overdosed, than other
users of benzodiazepines. Of those subjects who had injected
benzodiazepines, 55% were no longer current benzodiazepine injectors.
Concern for general health emerged as the most common reason for having made
a transition away from injecting, and for being likely to make such a
transition.

Addiction. 2000 Dec;95(12):1785-93. Related Articles, Links


The nature of benzodiazepine dependence among heroin users in Sydney,
Australia.

Ross J, Darke S.

National Drug & Alcohol Research Centre, University of New South Wales,
Sydney, NSW 2052, Australia.

AIMS: To determine the extent to which heroin users meet criteria for
benzodiazepine dependence, to examine the appropriateness of these criteria
for assessing benzodiazepine dependence among this population, and to assess
what other substance use, depressive and anxiety disorders are associated
with benzodiazepine dependence. DESIGN: Cross-sectional survey. SETTING:
Sydney, Australia. PARTICIPANTS: Two hundred and twenty-two heroin injectors
recruited through adverti*****ts, needle exchanges, methadone maintenance
clinics and by word of mouth. FINDINGS: Twenty-six per cent (52/202) of
those who had used benzodiazepines received a life-time diagnosis of
benzodiazepine dependence, with 22% of current benzodiazepine users being
dependent. A principal components ****ysis revealed that a unidimensional
construct underlies the benzodiazepine dependence syndrome. Those
respondents with life-time benzodiazepine dependence were more likely than
others to meet criteria for anxiety or depressive disorders. CONCLUSIONS:
The inclusion of the benzodiazepine dependence syndrome in DSM-III-R (and
DSM-IV) is justified. A disturbingly high proportion of heroin users meet
the criteria for benzodiazepine dependence, a condition that should be
regarded as a significant marker for co-morbidity among this group.
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15 25th February 13:44
corey
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Posts: 1
Default Restoril aka Temazepam - Need Advice


That's jake in a nutshell.
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16 25th February 13:44
corey
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Posts: 1
Default Restoril aka Temazepam - Need Advice (depression)


Another brilliant observation about jake.
What in the world is his motivation for the stupid things he says
about depression medicications?
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17 26th February 01:10
larry hoover
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Posts: 1
Default Restoril aka Temazepam - Need Advice (temazepam)


I stand corrected. I was unaware of liquid temazepam altogether, and I
didn't come across it in any of the abstracts on Pubmec, either.

It that's all the commentary you see fit to make, then I adjudge my postings
to be resounding successes.

Lar
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18 26th February 01:10
jake
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Posts: 1
Default Restoril aka Temazepam - Need Advice (hallucinations)


Temazepam (jellies or wobbly eggs)

Sold in 10-30mg capsules; also 10-20 mg tablets. Muscle relaxant and
sleeping pill. Popular in Scotland when coming down after E, and its
use is spreading. Normally swallowed, but when melted and injected can
solidify and cause circulation problems. In 1994, 50 deaths were
linked to Temazepam in the Glasgow area alone.


If you are content to redefine addiction as dependence fine..
the practical effect on the longterm user is the same

Temazepam can make users feel violent and aggressive, and is also
reported to produce memory loss and blackouts. Many people have
described a sense of invulnerability, which has led to them feeling
that they are invisible and given them the confidence to shoplift.


Benzodiazepine dependence

http://www.dotpharmacy.co.uk/upbenz.html

Long-term use of benzodiazepines leads to tolerance and dependence.
The nature of benzodiazepine dependence is poorly understood, although
several theories have been advanced.

One such theory involves the concept of an endogenous benzodiazepine
ligand, even though no such compound has ever been isolated. Other
theories, for which there is some experimental evidence, suggest that
changes occur in the density of the GABA receptors.

After continual use, the benzodiazepines lose their effectiveness,
possibly by down-regulation of the GABA receptors. This has been shown
in experimental animals, where continuous administration of
benzodiazepines has effectively desensitised the GABA receptor and
enhanced the effects of inverse agonists (ie inducing opposing
effects).

A well-recognised withdrawal syndrome does exist and produces a number
of rebound effects such as anxiety, depression, insomnia, tinnitus and
paraesthesia (pins and needles), as well as visual disturbances and
flu-like symptoms. These withdrawal effects can be induced in long
term users, particularly with the shorter acting drugs such as
temazepam, in as little as 24 hours. Longer-term effects include
various psychological effects such as hallucinations, paranoia,
depression and apprehension.

Several factors are important in development of the withdrawal
syndrome. Clearly, the most important factor is duration of drug
treatment. However, dosage is clearly another important factor; animal
studies show that physiological dependence can be induced at high
doses. Since drug abusers often consume very large doses, it is likely
that some form of physiological dependence is inevitable.

The theory that dependence is purely psychological does have some
currency, as does the notion of the dependence-prone personality.
However, many people have ascribed the rebound effects induced by
withdrawal as simply a return to the individual's original mental
state.

Treatment of benzodiazepine misuse
While methadone can be used to withdraw patients from illicit opiates,
there is no specific drug treatment available for
benzodiazepine-dependent individuals. The two key features of the
treatment strategy involve a gradual reduction of dosage, and anxiety
management.

As the only real difference between the benzodiazepines is in their
half-lives, it has become standard practice to change the patient to
an equivalent dose of a longer-acting benzodiazepine such as diazepam.
This policy has been recommended in the recently published guidelines
on the management of drug misuse produced by the Department of Health.

Equivalent doses of diazepam for some of the other benzodiazepines are
shown in Table 2.

The advantage of changing to a longer-acting agent is that it allows
for a more gradual dosage reduction. The conversion to diazepam can be
used successfully for patients' prescribed the****utic doses, as well
as those taking very high doses as shown in the box.

Managing benzodiazepine withdrawal
Having converted the patient to an equivalent dose of diazepam, reduce
the dose by about 10 per cent per month provided the patient is stable
and remains free of withdrawal symptoms. Sudden cessation of high-dose
benzodiazepine use can result in convulsions.

If the patient is stable on 60mg diazepam, reduce by 5mg per month and
then review again after six weeks.
For patients stable at even higher doses, eg 100mg diazepam, reduce
the dose by 5-10mg monthly.
If a patient is stable on a much lower dose, such as 20mg diazepam,
then reduce by 1-2mg monthly.
Continued review is vital (at least every three months) to ensure that
patients remain stable after dose reductions. If patients become
unstable, ie they begin to experience withdrawal symptoms, the rate of
dose reduction should be slowed down. Complete withdrawal can take up
to a year.
If a patient is co-prescribed methadone, the dose should remain
constant while the benzodiazepine reduction takes place.

__

"When society turns a blind eye to the dangers of drugs and rushes to embrace a
pharmaceutical cure for nearly every condition, there is almost no end to the
harm that may result".

Thomas.J.Moore
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19 26th February 01:11
jake
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Posts: 1
Default Restoril aka Temazepam - Need Advice (eye)


In June 2002, federal prosecutors in Arizona moved to seize several
million dollars in assets from the Web sites, owners, doctors and
pharmacies. The prosecutors estimated that in a 14-month period, the
operation handled more than 35,000 prescriptions and dispensed 2
million doses of controlled substances. According to court records,
the Web sites grossed an estimated $4 million, with Finnell receiving
$726,000 and Dixon, $719,000.

In its civil complaint, the government said customers paid inflated
prices and tolerated "the delay because either they had no doctor who
would prescribe the drugs . . . or they sought to avoid scrutiny."

__

"When society turns a blind eye to the dangers of drugs and rushes to embrace a
pharmaceutical cure for nearly every condition, there is almost no end to the
harm that may result".

Thomas.J.Moore
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20 26th February 18:31
mozilla ed
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Posts: 1
Default Restoril aka Temazepam - Need Advice (temazepam)


i can back this one up. i useda inject temazepam.
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