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1 3rd August 17:16
robinmst
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Posts: 1
Default Stress, Personality and HCV Severity (personality depression virus hepatocellular carcinoma cancer)


Psychosocial Stress, Personality, and the Severity of Chronic
Hepatitis C
Psychosomatics 45:100-106, April 2004
Jun Nagano, M.D., Shoji Nagase, M.D., Nobuyuki Sudo, M.D., and Chiharu
Kubo,M.D.

"...The severity of liver disease related to the hepatitis C virus is
extremely variable. While 20%--30% of chronically infected people
continue to have minimal liver injury with normal serum alanine
aminotransferase levels for decades, the remaining 70%--80% develop
chronic hepatitis with elevated alanine aminotransferase levels, of
whom 20% or more progress to cirrhosis over 20 to 30 years. The only
available treatment for elimination of the hepatitis C virus is
interferon therapy, but its efficacy so far remains limited. For
patients in whom hepatitis progresses, hepatocellular carcinoma is the
leading life-threatening complication. Generally, hepatocellular
carcinoma occurs in patients with severe fibrosis and inflammation,
especially in those with cirrhosis. Virological factors, such as the
hepatitis C virus genotype and the serum hepatitis C virus RNA level,
do not seem to be associated with the severity of hepatitis or
progression to advanced stages. This suggests that particular
immunological factors of the host play a major role in determining the
severity of hepatitis C and, in turn, hepatocarcinogenesis.

Ac***ulating evidence has linked psychosocial factors to the onset,
course, and outcome of chronic and latent viral infections, such as
genital herpes virus, varicella-zoster virus, and human
immunodeficiency virus. However, little is known about the role of
psychosocial factors in the course of chronic hepatitis C virus
infection. Epidemiological studies suggest that some psychosocial
factors are associated with an increased risk of cancer and mortality.
Grossarth-Maticek and colleagues have shown that their type 1
personality is positively and strongly associated with cancer risk.
The type 1 personality is a type characterized by "object dependence,"
i.e., a tendency to have highly valued objects (persons or conditions)
by which one's emotional status is greatly and chronically swayed, as
well as by a tendency to react to stressors with hopelessness and
depression. Additional characteristics of the type 1 personality
include marked repression of emotions and altruistic behaviors in
interpersonal relationships. Since chronic psychosocial stress may
affect the severity and progression of chronic hepatitis C and since
the severity of hepatitis is regarded as a crucial factor in the
hepatocarcinogenesis related to hepatitis C virus, we hypothesized
that the type 1 personality would be positively associated with the
severity of chronic hepatitis C..."

More at: http://www.natap.org/2004/HCV/041204_01.htm
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