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1 31st May 16:48
judy haight
External User
Posts: 1
Default Zonulin Blocker (diabetes celiac)

Just curious ...

Did anyone else here catch the news reports for a potential zonulin
blocker that might be on the market by the end of next year that might
make it possible for us to eat gluten again?

Dr. Fasano's group in Maryland has been doing the research.
Apparently in celiac disease and MS and juvenile diabetes, there is a
substance called zonulin that is present in greater amounts than is
normal. When high amounts of zonulin are present, then the space
between the cells in the intestines increases resulting in leaky gut.

So the hope is that by blocking production of zonulin, leaky gut would
no longer occur. Apparently they are hoping to make a pill or
something that a person could take about 20 minutes before eating.
According to the article I read, they finished the rat trials and are
starting human trials next.

How would you all feel about a pill that let you eat gluten again?
Would you trust it? What if you had to be diagnosed to get it? Would
you feel like paying for it if your insurance didn't cover it? We've
talked this over at home and generally feel that it might be useful on
the rare occasions that we dine out, just to protect ourselves, but
we're happy enough to avoid gluten otherwise.

I googled this and came up with some links in case anyone wants to
read further:

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2 31st May 16:49
External User
Posts: 1
Default Zonulin Blocker (diabetes celiac diet down)

I saw that article. I'm ambivalent about the availability of such a pill.
I think it's likely that if this pill becomes available, most doctors (at
least in the United States) will summarily prescribe the drug for their
newly diagnosed celiac patients without discussing the gluten free diet as a
viable option. After all, isn't it the birthright of every American to shove
anything indiscriminately down his piehole and take a pill to counteract the
symptoms that arise from eating toxic food? The prospect of going gluten
free for life is overwhelming initially, so I think the option of taking a
pill before meals will be seductive for a lot of people who are newly
I feel fortunate to have adjusted to a gf diet before this pill hits the
market. Personally, I'm skeptical that the drug regimen described in this
article will actually promote health in the patient. But 2 years ago if a
drug had been presented to me as an option for symptom suppression I
probably would have jumped at it.
At present, celiacs who take their condition seriously accept the zero
tolerance policy regarding gluten in their diet and thus present a united
front to food manufacturers. I believe that the introduction of a drug to
mitigate or eliminate symptoms of the disease will spit the celiac community
into two camps - those who are willing to take a pill and those who are not.
I might be willing to take it for travel or special eating out occasions,
but probably not before every meal. I'd still like to have gf options
My fear is that the availability of a "cure" will diminish the availablility
of gluten free products for people who don't want to take the drug. In other
words, instead of more gluten free products available in stores and by mail
order, instead of more restaurants willing to provide gf menu options, I
fear that the bottom will fall out of the gluten free market.
It's easy to see why pharmaceutical companies would be interested in this
type of drug research in light of the recent study showing rates of celiac
orders of magnitude higher than previously thought. I'm sure the executives
are starting with the assumption that everyone diagnosed with celiac will
want the drug, and at 1 in 133 Americans times 2-3 meals a day (plus
snacks?!) times 20 to 70 years of remaining life span....$$cha-ching! AND
it's purported to treat diabetes. That's a pharmaceutical company's wet
Right now you have to club your physician over the head with to get a
stinking blood test, but when(if) this drug hits the market, look for
aggressive advertising promoting screening for celiac disease.


Home is where the food is.
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3 4th June 18:12
emma thackery
External User
Posts: 1
Default Zonulin Blocker (eye)

<brevity snip>

I've been keeping my eye on that too but I'm not sure what to make of
it. I'd be concerned about long-term consequences, especially given all
the drugs they've had to take off the market lately due to failure to
adequately test for or release data about potential long-term hazards.

That said, I am truly ever-hopeful. There are a couple foods I really
miss that I'd love to have every long while and then. And yes,
insurance for dining out, sounds good too.

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4 4th June 18:12
emma thackery
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Posts: 1
Default Zonulin Blocker (diet prozac ritalin)

Darn good point. All most doctors do, except surgeons of course, is
shove pills at you for just about anything.
<brevity snip>

OMG what a frightening thought! But a very realistic one I think.

You are right on target. Pretty scary methinks. And following your
line of (good) reasoning, it gets even worse. It could end up like the
ritalin/prozac debacle where parents were forced to give their children
untested-on-kids drugs to satisfy teachers who want only zombies in
their classes. Instead, maybe the insurance companies, soon to be run
by the pharmaceutical companies just like our government (heh) could
demand you take the drug or forgo any future medical payouts for any
conditions they will say arise from the Celiac. An even worse scenario
involves the wheat industry, which already spends gazillions condemning
the low-carb diet and lobbying congress against food labeling, investing
heavily in development of this new "drug".

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5 4th June 18:12
External User
Posts: 1
Default Zonulin Blocker (celiac allergic)




of course, there will still be that constituency of the wheat-allergic
distinct from the celiac community who will require wheat free products. I
don't know if their requirement for "wheat free" is as stringent as for
celiac. And some of the "wheat free" products have malt added for flavor.
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6 4th June 18:13
External User
Posts: 1
Default Zonulin Blocker (calcium)

Am I missing something? Blocking the symptoms doesn't mean the damage to
the villi isn't taking place. Since I _was_ an asymptotic Celiac, it was
the nutritional deficiencies that brought it to attention. I can use an
antodiarrheal to manage exposure symptoms now but I still hate the way I
feel when I can't absorb B-12, folic acid, iron, calcium etc.

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7 4th June 18:13
emma thackery
External User
Posts: 1
Default Zonulin Blocker

The pills are allegedly supposed to prevent reactions entirely,
preventing any damage at all.
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8 4th June 18:14
judy haight
External User
Posts: 1
Default Zonulin Blocker

Everyone has made a lot of good points! I wonder whether it will be
available over-the-counter, like Lactaid, or by prescription only.
We'll have to wait and see how it works and how test subjects (not
me!) accept it ...

It's interesting that Lactaid has been on the market for a long time,
but the section of my big supermarket that has grown the most in the
last handful of years is the alternative milk section (soy milk, rice
milk, nut milk). It used to be nearly invisible but now between
refrigerator space and regular shelf space, I think it's bigger than
the dairy milk section.

If pills for gluten intolerance work as well as Lactaid, we won't have
to worry too much about losing GF products

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9 4th June 18:14
emma thackery
External User
Posts: 1
Default Zonulin Blocker

Lactaid really ****s. Before I knew I had Celiac, and thought I was
just lactose intolerant, I tried every lactase enzyme supplement known
to humankind. The only one worth a damn was made by Nature's Way
("Lactase")--- by far, the highest FCC units and also marketed in a
capsule form which is great if you have to swallow 5-7 of them like I

But now, my lactose intolerance is almost gone. I still take 2 on the
rare occasion I have milk. I plan on reducing that to one in a month or
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10 4th June 18:14
External User
Posts: 1
Default Zonulin Blocker (celiac gluten-free diet antibodies autoimmune)

As I understand it, these reasearchers are saying that the leaky gut caused
by overproduction of zonulin is responsible for the autoimmune response
which then damages the gut. But in the first link that Judy included
( there is this:
"Patients with active celiac disease showed higher levels of zonulin and
anti-zonulin antibodies compared to non-celiac patients and patients in
remission, who were eating a gluten-free diet." So basically when gluten is
removed from a celiac's diet, the overproduction of zonulin stops, leaky gut
goes away, and the person gets better. We've all lived it. It sounds to
me like this pill blocks the zonulin action, but it doesn't actually stop
the overproduction of zonulin which will take place when the celiac once
again ingests gluten.
Does that not indicate that the celiac's body is still reacting to gluten?
Maybe you don't get the immune response because the gluten is retained in
the gut, but something is going on. Maybe overproduction of zonulin isn't
the only thing that happens.

Also, this research makes me wonder about people who technically have a
negative blood panel because their anitbody levels are below the threshold
for celiac diagnosis. Still, they are producing antibodies for something
that, according to the article, shouldn't be floating around outside the
intestines. Might they not also have a leaky gut that needs to be


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