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Hostile men face heightened heart attack risk

ANI
The Times of India
Thursday, July 31, 2003

Washington - A new research in psychosomatic medicine has
revealed that healthy but hostile and depressive men face
a heightened risk of heart attack.

"The new findings suggest the possibility that mild to
moderate levels of depression symptoms combined with
feelings of hostility in men may raise their levels of a
protein that is associated with clogged arteries and a
greater risk of heart attack," said to Edward C Suarez,
of Duke University Medical Center.

"Although studies have shown that hostility and
depressive symptoms are associated with greater risk of
heart disease, the reasons for these associations are not
well understood. It is increasingly apparent, however,
that inflammation in the bloodstream is linked with heart
disease," Suarez noted.

Previous studies indicate that the protein, called IL-6,
is at least a marker of inflammation, and may even be
involved in the inflammatory processes that cause artery
thickening and buildup.

However, researchers know little about IL-6's relation to
psychological risk factors.

Suarez examined the link between depression and hostility
and IL-6 levels in 90 healthy, non-smoking men aged
between 18 to 45.

After giving a blood sample, the participants answered
two questionnaires to determine their level of depressive
symptoms and hostility.

Men who scored highest on both questionnaires, indicating
increased symptoms of depression and higher levels of
hostility, had IL-6 levels that were two to five times
higher than men who scored low on both questionnaires or
scored high on only one questionnaire.

The association between the psychological factors and IL-
6 held steady even after accounting for other factors
associated with IL-6, such as age, body weight,
cholesterol levels and blood pressure.

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