ranhub11

Hi,

A few weeks back i approached Dr Bill Sardi about copying his
vitamin C story in his Newsletter for a p post. We got to talking
about
psoriasis and he reported that he had a few folks who
improved (their psoriasis) due to taking a supplement that he
works with designed for moisturizing the skin.

One thing lead to the next and
I've taken six caps of HA twice a day for 13 days. HA is
working beyond any expectations i had. After the first week i added
in NAC twice a day and it boosted the HA a little more.
My regular P diet plan is more or less in place.

I have a ton of tests to run with HA. For all i know it could reverse
tomorrow. Right now i'm living large and clear-ish and
loving it. I'm gonna stick out my long neck and speculate
that this is gonna be big. Longnecker big? Only if you want
to pay me. Why shouldn't i get rich off you while clearing me? lol

Here's what i'm taking,
3 caps of Purity's Vital H.A. Max formula twice a day.
And 3 caps of Purity's Ultimate H.A. Forumula twice a day.
I eat two meals a day and thats when i've taken (each six caps) so
far.

Here are some links,

http://www.purityproducts.com/product.asp?sku=134

http://www.purityproducts.com/read_m...ultimateHA.htm

I haven't tried this yet, but it may augment taking it orally,
http://www.purityproducts.com/product.asp?sku=252

Here are a few abstracts,

This one looks key,
http://www.ncbi.nlm.nih.gov/entrez/q..._uids=15149843
Hyaluronan suppresses epidermal differentiation in organotypic
cultures of rat keratinocytes.

Hyaluronan (hyaluronic acid, HA) is an abundant matrix component
between keratinocytes of the epidermis in vivo, but its function there
remains unclear. We used a lift culture model, in which rat epidermal
keratinocytes (REKs) stratify at an air-liquid interface, to ask
whether HA may regulate epidermal proliferation and/or
differentiation. In this model, early markers of differentiation
(keratin 10), and later markers (profilaggrin, keratohyalin granules,
cornified layers) are faithfully expressed, both temporally and
spatially. HA, measured using two different analytical techniques,
accumulated to high levels only in the presence of an intact basement
membrane that seals the epidermal compartment. To test whether HA has
a functional role in differentiation, Streptomyces hyaluronidase
(StrepH, 1 U/ml; digests >95% of HA within 4 h) was added daily to
lift cultures during stratification time-course experiments over 5
days. In StrepH-treated cultures, the expression of profilaggrin and
the number and size of keratohyalin granules were significantly
increased relative to controls using semiquantitative histological
analyses. The StrepH-related accumulation of K10 protein and
profilaggrin/filaggrin were confirmed by Western analyses. Thus, it
appears that the presence of intercellular HA in the epidermis acts as
a brake upon intracellular events that occur during keratinocyte
differentiation.

PMID: 15149843

Strep is one of the triggers of psoriasis. And anything that slows
down
differentiation is good for psoriasis.

This next has a good idea for psoriasis also, upregulation of a key
gene (HAS2)
http://www.ncbi.nlm.nih.gov/entrez/q..._uids=15020224
Compound K induces expression of hyaluronan synthase 2 gene in
transformed human keratinocytes and increases hyaluronan in hairless
mouse skin.

Ginsenosides, the major active ingredients of ginseng, have a variety
of biomedical efficacies such as anti-aging, anti-oxidation, and
anti-inflammatory activities. To understand the effects of compound K
(20-O-beta-D-glucopyranosyl-20(S)-protopanaxadiol), one of the major
metabolites of ginsenosides, on the skin, we assessed the expression
levels of about 100 transcripts in compound K-treated HaCaT cells
using cDNA microarray analysis. One gene up-regulated by compound K
was hyaluronan synthase2 (HAS2). Semi-quantitative RT-PCR showed that
compound K increased HAS2 mRNA in time- and dose-dependent manners.
ELISA and immunocytochemistry using hyaluronan (HA)-binding protein
showed that compound K effectively increased HA production in HaCaT
cells. Finally, treatment of compound K on hairless mouse skin
increased the amount of HA in the epidermis and papillary dermis. Our
study suggests that topical application of compound K might prevent or
improve the deteriorations, such as xerosis and wrinkles, partly
ascribed to the age-dependent decrease of the HA content in human
skin.

PMID: 15020224


Looking at the surrounding genes may hold some clues.

OMIN search of (HAS2)

hits,
1: *601636
HYALURONAN SYNTHASE 2; HAS2
Gene map locus 8q24.12
Map:
http://www.ncbi.nlm.nih.gov/entrez/q...st_uids=601636


2: *602428
HYALURONAN SYNTHASE 3; HAS3
Gene map locus 16q22.1
map:
http://www.ncbi.nlm.nih.gov/entrez/q...st_uids=602428


What do we have in the group for it?
(J's mentioned it! So has evetsm!)
http://groups.google.com/groups?hl=e...ases.psoriasis

Hyaluronic acid --diet anyone?
http://groups.google.com/groups?q=Hy...eja.com&rnum=2

How to get Hyaluronic acid in your diet: Hyaluronic Acid supplements
are now available in easy to consume capsules.

http://www.hyaluronic-acid.org/

Web search of HA,
http://www.miragemedical.co.uk/restylane.htm

Gif: http://www.medscape.com/pi/editorial...ll/slide06.gif
Taken from:
http://www.medscape.com/viewprogram/264_pnt


Have a Happy HA day.

jxstern

So I can maybe throw in some alpha-lipoic acid I have sitting around.


The logic is sweet, and if I get major clearing from it I'll want to
buy the world a Coke, and maybe a bit more for you personally!

Maybe we can get TJ's to start carrying it.

I do like the sound of it, BUT wonder how much of it gets through the
stomach undigested. Well, maybe if digestion breaks it apart, the
body puts it right back together, and closer to where it's needed!??!?!


Blended with this and that, no pure source?

Well, screw that if it's working, but maybe go back later and figure it out.

Wondered about it topically, but it's a big, fat polymer so it's not
going to be absorbed.


Moi? As an ingredient for a topical someone else mentioned, and I
didn't even pick it out as the significant ingredient.

Chemicals got their own web sites? Oh, brave new world!

Well, I think I'll give the turmeric another week or three, but you've
definitely got me to put HA on the top of the list of things to try
next!

And, meanwhile, eat less meat, maybe a bit more magnesium, less iron,
fewer total calories. A high carb diet, boy, you *really* gotta
reduce the total calories! (and in fact, I have to wonder if that's
not the real reason those Japanese villagers lived longer, it's pretty
clear now that that works, but I guess the HA helps with quality of
life, maybe, hopefully). See if my local Japanese joint has a
vegetarian bento lunch ...

http://www.kabukirestaurants.com/pub...91528338117861

Well, salmon teriyaki, with that farmed salmon (ugh), plus or minus
the tempura, good, but tempura includes an evil iron-containing
shrimp, not to mention evil trans-fatty acids in the fry oil. Hmm,
maybe I can negotiate a pure veggie tempura deal, triple sweet-potato,
yum, and maybe they can throw in some onions and broccoli, which they
don't now tho other places do.

Local chain, doesn't even reach to San Diego, I do recommend the bento
lunches and boat dinners and such, but do NOT go there for sushi!!!

J.

ranhub11

If you have ROS why not? Ala + ALC would be optimal. You may make
it to 100 without the HA skin fix treatment.

Sweet! Its the real thing.

I'll be eating it raw from some cocks comb before long.


You got me. At the time i figured it couldn't hurt.


They use young chicken breast bones. Besides the cocks combs
and some microbial preparation, its the most plentifull source.


Ok, lets try a few more abstracts.

Still worth a try. If it pulls in moisture to the skins top surface
and has HA trying to get in from the inside, maybe some sort of
synergy will develop. And since my skin is looking so nice, it
may make it look even better.

I did use the wheatgrass yesterday and its looking fine.

Recognize that elevated HA levels in blood serum indicates more HA is
being degraded.

For those who wish to learn more,
HOW TO LIVER 100 YEARS WITHOUT GROWING OLD
(www.hereandnowbooks.com).


Clin Rheumatol. 2000;19(6):455-7. .

Serum levels of hyaluronic acid in patients with psoriatic arthritis.

Elkayam O, Yaron I, Shirazi I, Yaron M, Caspi D.

Department of Rheumatology, Tel Aviv Sourasky Medical Center, Tel
Aviv, Israel. oribe14@netvision.net.il

The purpose of this study was to evaluate the serum levels of
hyaluronic acid (HA) in a group of patients with psoriatic arthritis
(PsA), with special emphasis on the relationships between HA levels
and clinical parameters of joint and skin activity. Thirty-four
patients with PsA, 34 patients with rheumatoid arthritis (RA) and 49
healthy volunteers participated in the study. Assessment of joint
disease in patients with PsA included duration of morning stiffness,
number of tender and swollen joints, right and left grip, the presence
of inflammatory back pain and Schober's test. The current severity of
skin involvement was graded according to the Psoriasis Area Severity
Index (PASI). Serum levels of HA were measured by a radiometric assay.
The mean HA serum levels of patients with PsA and RA were
significantly increased in comparison with healthy controls (107 +/-
39.6 microg/dl in patients with PsA, whereas in patients with RA it
was 168 +/- 32.4 microg/dl and 36.7 +/- 5.5 microg/dl in healthy
controls). A highly significant correlation was found between levels
of HA and index of skin involvement, but no association was found
between HA levels and clinical parameters of joint severity. We
conclude that in this cohort of patients with PsA, HA levels clearly
reflected psoriatic skin involvement although it did not correlate
with joint disease.

Arch Dermatol Res. 1994;286(1):21-9. .

Hyaluronan and CD44 in psoriatic skin. Intense staining for hyaluronan
on dermal capillary loops and reduced expression of CD44 and
hyaluronan in keratinocyte-leukocyte interfaces.

Tammi R, Paukkonen K, Wang C, Horsmanheimo M, Tammi M.

Department of Anatomy, University of Kuopio, Finland.

The distributions of hyaluronan (HA) and its presumptive receptor,
CD44, were studied in skin samples from 13 psoriasis vulgaris
patients, using an HA-specific probe (HABC), and monoclonal
antibodies, respectively. The general distribution of HA and CD44 in
psoriatic lesional epidermis resembled that in normal epidermis.
However, areas of epidermis invaded by leukocytes showed a local
depletion of HA and CD44, particularly at the contact areas of
keratinocytes to lymphocytes and neutrophils. Removal by cellular
uptake or extracellular degradation of CD44 and HA may be required for
tight adherence between a keratinocyte and a leukocyte. On the dermal
side, the tips of the prolonged dermal papillae in psoriatic lesions
were intensively stained with HABC. The dilated capillaries and the
space below the tip basal lamina, in particular, were heavily covered
with HA. Occasionally, a similar intense staining was seen around an
enlarged capillary in uninvolved psoriatic skin. CD44-positive
leukocytes were found around the affected capillaries. The
accumulation of HA in the dermal papillae may support the growth of
psoriatic lesions, since HA stimulates the growth of capillaries as
well as attracting inflammatory cells.

Br J Dermatol. 1985 Jun;112(6):663-71. .

Circulating hyaluronate in psoriasis.

Lundin A, Engstrom-Laurent A, Hallgren R, Michaelsson G.

A radioassay method allowing measurements of low concentrations of
circulating hyaluronate was used in a study of serum hyaluronate
concentrations in 44 patients with psoriasis. Twenty-three of them had
only skin lesions and 21 had both skin lesions and arthropathy. In
both of these groups significantly elevated serum levels of
hyaluronate were found. The highest values were observed in those with
widespread and active skin disease and/or active arthritis. Serum
hyaluronate positively correlated with the plasma concentrations of
alpha 1-antitrypsin and haptoglobin and also with ESR, which may
indicate a relationship between acute inflammation and increased
production of hyaluronate. Seven patients with widespread atopic
dermatitis included for comparison had normal hyaluronate values. In
blister fluid from lesional skin in two patients with acute psoriasis,
very high concentrations of hyaluronate were found, in comparison with
the concentrations in blister fluid from non-involved skin. The
increased concentration of serum hyaluronate in psoriasis indicates
involvement of dermal and synovial tissue in psoriasis, in addition to
the epidermal changes


&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&

Somethings amiss here. HA is high in the skin of psoriatics and i'm
taking HA and my P is going bye bye.

Rather counter-intuitive at this point. Degraded HA in the skin seems
to be a problem for psoriatics. I wonder whats happening with the
HA supplements as far as clearing my P?

Oh and one more thing. In my haste i posted that Bill Sardi was
Dr Bill Sardi. My mistake. Bills a health journalist. His articles
are so insightfull, its hard not to think of him as anything other
then a healer. And better yet, many of his articles aim for the
prevention of disease and that makes as much sense as living to
100 and not enjoying the triP.

Ha-PP-y P trails

skeatsanco

news:<a0jlh0ljliemgasj2er2t9id8ntqr0j05m@4ax.com>. ..


Saw something on Medscape that raised questions about the bovine tye
derivative though when used for cosmetic reasons.
"Granulomatous Foreign Body Reaction Against Hyaluronic Acid"
(forgotten my password to get the url at present)!

Skeatsan''co

jxstern

That's my favorite criterion.

I mean capsules with only HA.

I have thought for a long time that part of the flaking, in
particular, of psoriasis might be caused by depletion of some common
nutrients. Might cause the body to turn to secondary or tertiary
defense systems, which are insufficiently local. Wild speculation
here.

J.

ranhub11

Most likely due to injected HA. Not a problem for us at this point. Somehow
whats going thru my Gi tract is making
a big difference. I do feel that i was
leveling off at the one week mark and
the NAC (N-acetyl-L-cysteine) 500mg.s twice a day picked up the slack.
Recent stand alones with NAC have been
not nearly as rewarding. But using NAC with IP6 (an iron chelator to slow down
the effects of a diet heavy on meats) still do the job as well.
Proves to me that the gut flora fed the meaty iron and a little Gi tract
permeability is one
of the keys to psoriasis flares or feeding a plaque its daily sustenance.

Thusly if the HA is doing anything in the skin and it seems to be in my one
case,
then it may be holding more moisture.

And we can only speculate as to that.

We've all remarked how well our non P skin looks. And how the p plaques may be
compensatory for worse things internally.

So, if using HA stoPs toxins (SA, SAGs,
CLA or whatevers activating the T cells)
and making it mechanically easier for the skin to remove them prior to damage
(plaques) occuring, we're in the money.


Nah, i doubt it.

Probably a placebo! lol

My first really good one if it is!

I hope my brain stays tricked uP!

Think i'll go clean uP and mosisturize with some of the tons of stuff they gave
us at the NPF convention. A friend was over for dinner last nite and came back
from the
bathroom and said, "Hey what can i take for my husbands psoriasis?"..

What? i said. "I didn't know he had it".


Yeah, he has a small patch once in awhile.

So i said, buy some of this HA and when
he flares give him some and let me know
how he does.

I'm colecting data! I have to know what
haPPens next.

randall

ranhub11

Oh. I think some of the co-factors help out.
I noticed a little CoQ10 in it and had some
extra 50mg caps laying around and added it in. I figured that couldn't hurt
either.
I had been taking some Red Yeast rice (which is a statin precursor-- statins
are made from it) and i figured i may need the extra CoQ10 as statins deplete
it.

So that may be key, here also.


See my previous post to skeet for real
wild speculations.

And those ninety cap bottles that i'm taking six a day from will soon be gone.

Do i stop or keep going for another few weeks? Will i build uP some sort of
charge that protects me for X amount of time?

And if i start to regress will i jumP back on the wagon like a junkie?

And did i blow that last metaphor?

Or do we have a new tool in the P black box of known helpers?

That LPS thread with evetsm always forces my grey matter to go overtime. And
comparing Th1 P with the very lifestyle disease--Th2 diabetes does bring up
lifestyle overlaPs. Like can we eat a veggie
(pagano-ish) diet to some levels of clearing? Or will relaxation, mediation
really help more then a few percent?

Destressing the HPA-axis is lifestyle and
skeets retirement may have made a large
difference. OTOH my dads P onset at
almost 50 and progressively worsened right thru retirement.
My older sibling followed Father onset wise but changed his diet and his P
never spread beyond his knee and is nearly invisible now.

He's one of the first people to actually take my P diet idea's and use them
beneficially.

And he's on the proflora whey and didn't require the implant. Being a non
drinker is a large plus as the flora is degraded so easily by it. Notice how
all psoriatics are
flared by alcohol. Yet having the P blues is fertile ground for drinking your
poor problems away. Cept in our case it makes it all worse. We're forced to be
happy and
diet conscious or we're looking at more of the same old P thang.

No thanks, screwing myself is to much of a Pain in the skin.

ranhub11

Hi,

I'm at the two week mark and i'm gonna
go ahead and do another two weeks
(12 Caps a day split between two meals)

I imbibed a known permeability inducer last night which caused some light
flakiness on half the plaques and a little itchiness the next day.

All in all still looking pretty good and happy
to go on with it. I better watch the diet a little better. But still, my goal
is to be able to eat more normal without the guilt of the P blues hanging every
omega-6/arachidonic acid/P trigger corner. Will Ha provide that relief? Time
will certainly tell. According to the first abstract in the first post to this
thread i'm doing something that sounded very positive with rebuilding the
matrix of the tissues and
slowing down differentiation.

If thats true, wahooooo or yoo hoo!

I'll be ramping up my tests of nasty foods to record levels. hehe
or is that HA HA!

Then again i may mellow and go with the clear flow and chill out.

Who knows?

HAppiness does strange things as far as behaviour is concerned.

Taking those P's outa haPPiness will be
all right with me. HA i ness!

Will keep you posted,
randall

joegabe

Randall - Any new news?
I started taking 6 Purity's Vital-H.A. Max Formula a day and it *appears*
to be helping a little. ( 2 weeks ) I've got Psoriatic arthritis ( hands )
and the flaking does seem to be better that before I started. Nails are
still shot and falling out. I see that you are/were taking 2 times what I
have been taking and am now wondering if I should place another order and
up my intake to see if I get better results.

Thanks

ranhub11

I'm always testing. What you get is a single frame of my current little
darlings.

Agreed. It did little for my PsA also. Yet it helped my p so much i didn't
mind.

At the present time i'm doing one cap of HA a day with one cap of the kirkland
(costco) brand of Glucosamine HCL 1500 mg and Chondroition Sulfate
1200 mg. And i'm holding my own nicely.

The major problem is i'm eating the wrong foods, because i can without
flaring and my blood pressure is stage one/stage two.

Agreed. HA did nothing for my nails positive that i noticed.

You could try. But look at me now. One cap a day and my flaking is very
little. The redness is basically all there except for the few places that
totally cleared.


And i use the wheatgrass spray and moisturizer to keep the red under control.

It works very nicely with HA.

Now if i go toward the veggie diet i just might live free and clear for a
while.

Or untill the holidays and i can't help not eat like a starving castaway.


randall