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1 30th July 11:18
External User
Posts: 1
Default Interesting article alcohol/smoking

I guess I owe P to my own stupidity


Acta Biochim Biophys Sin (Shanghai). 2004 Sep;36(9):597-602. Related
Articles, Links

Association between Alcohol, Smoking and HLA-DQA1*0201 Genotype in

Zheng GY, Wei SC, Shi TL, Li YX.

Bioinformatics Center, Shanghai Institutes for Biological Sciences, Chinese
Academy of Sciences, Graduate School of the Chinese Academy of Sciences,
Shanghai 200031, China.

Psoriasis is a chronic skin disease triggered by genetic, environment or
other risk factors such as infection, drugs, stress, moisture, alcohol, and
smoking. A major psoriasis susceptibility locus at 6p21.3 has been
identified. Further studies found that HLA-DQA1*0201 allele was associated
with psoriasis. However, there were few data exploring an association
between the environmental factors and susceptibility genes. In this study,
the samples of 189 patients with psoriasis and 333 healthy controls were
collected with their consent and were carried on ****ysis through polymerase
chain reaction sequence-specific primer (PCR-SSP) method. The proportion of
male psoriasis patients engaging in the smoking and alcohol was much higher
than that of the control group (P<0.005). The HLA-DQA1*0201 allele was
present at significantly higher frequency in the patients with psoriasis
(OR=4.25, P<1.0x10(-6)). Association was found between smoking, alcohol and
HLA-DQA1*0201 in male patients with psoriasis (OR>6.91, P<1.0x10(-4)).

PMID: 15346196 [PubMed - in process]
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2 1st August 23:06
External User
Posts: 1
Default Interesting article alcohol/smoking

Well, I'm not sure from the summary that this study says. Did they
have 189 + 333 = 522 patients with this HLA-DQA1*0201 gene, and found
that most of the smokers and drinkers showed psoriatic symptoms, that
is, were in the group of 189? That would be interesting, though one
would suspect some kind of sampling bias.

But no, they say even the gene's distribution was measured, so
apparently they (a) found 189 random people with psoriasis, (b) found
333 random people without psoriasis, then (x) found more of this HLA-*
gene in the 189 group, and (b) found more smokers within the HLA*
group in the psoriasis category.

However, the "significant" results might be rather small, maybe 100
people had the gene and 60 of them showed psoriasis, and of the 100,
40 smoked, and 30 were in the psoriasis group.

None of that ought to be terribly surprising. Only if the numbers were
a lot stronger, would this be any kind of news. It would still be an
informative and valuable confirming study, however.

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