28th July 09:22
Would Cur***in, PUFA, and Vitamin D3 be a winning combination?
Vitamin D receptor: key roles in bone mineral pathophysiology,
molecular mechanism of action, and novel nutritional ligands.
Jurutka PW, Bartik L, Whitfield GK, Mathern DR, Barthel TK, Gurevich
M, Hsieh JC, Kaczmarska M, Haussler CA, Haussler MR.
Department of Integrated Natural Sciences, Arizona State University at
the West Campus, Glendale, Arizona, USA.
The vitamin D hormone, 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)],
binds with high affinity to the nuclear vitamin D receptor (VDR),
which recruits its retinoid X receptor (RXR) heterodimeric partner to
recognize vitamin D responsive elements (VDREs) in target genes......
Moreover, the turmeric-derived polyphenol, cur***in, activates
transcription of a VDRE reporter construct in human colon cancer
cells. Activation of VDR by PUFAs and cur***in may elicit unique,
1,25(OH)(2)D(3)-independent signaling pathways to orchestrate the
bioeffects of these lipids in intestine, bone, skin/hair follicle, and
other VDR-containing tissues.
PMID: 18290715 [PubMed - indexed for MEDLINE]