Lurker 2007-09-26 05:13:02
Well as this happened 6 months ago I am sure it is way too late,,,,,does
this mean I have done permanant damage??
Bilz0r 2007-09-26 05:13:13
Vanilloids is my area of expertise, I’m shocked that it might have some
real world application.
On a similar note, I was chopping some habanero chillis, and I must have
got some crushed pepper, under my fingernail, because the whole end of my
thumb felt like it was burning for about 3 weeks.
As far as the pharmacology of your problem, there are two sides to it.
capsaicin does rapidly desensitise the receptor it binds to (VR1), which
intergrates noxious heat, acid and other chemical, into a painful stimulus.
So in the short term, a heavy dose of capsaicin will make your member less
sensitive to noxious heat and acid damage…
But, if the VR1 receptor is heavily activated, it CAN lead to cell death.
It is likely from the sounds of things, (if you are sure that you have lost
a degree of sensitivity in your p****) that this is what has happened.
Normally, peripheral nerves do regenerate (after things like crush, or
laceration damage), but Im not so sure about VR1 receptor mediate cell
I know that the tip of my right thumb (where I got the massive capsaicin
dose) is far less sensitive that my left, and I got my dosing about 6
Lurker 2007-09-26 05:13:15
Yikes! Well my p**** wasnt burning—it was just a warm sensation—could
that mean I didnt get enough capsaicin to do permanent damage? The skin does
look a little though–kind of shiny as strange as that seems. What the heck
was she thinking!!
Bilz0r 2007-09-26 05:13:15
Well if it was just warm, you’re -probably- fine.
What was she thinking? Id take it as a compliment if I was you. Its not
everyday women can’t keep their hands of you to a degree that they forget
to wash their hands….
Lurker 2007-09-26 05:13:22
If I can be blunt you are scaring the c*** out of me 🙂 It was warm for
several days though. There was no burning or pain at all—it was just a
warm feeling. Like a very mild dose of ben-gay or something. I grilled her
like cheese sandwhich afterwards and she said her hands were not hot or warm
at all after she cut the peppers—though I know the hands are weathered to
take a certain amount of abuse. She says she rinsed her hands in water but I
dont really believe her.
Lurker 2007-09-27 10:44:07
Again,,,very disturbing,,,,,,anyway to test whether I have caused any
permanent nerve damage,,,,,it has been about 4 months. Maybe it is just my
constant “churning butter” :0 that is causing my senstivity…..I also
assume I would burn and not just be warm if damage was to ensure,,,,,the
next day I poured milk on it when I realized that was the
antidote…..before I just washed it thourghly with soap and water—and
just my luck I always use olive oil soap and was out that night.
Lurker 2007-09-27 10:44:09
I am also curious if the Astoglide saved me—is capsaicin soluable in that
Lurker 2007-09-27 10:44:15
Astroglide: purafied water, Glycerin, Propylen Glycol, Polyquaternium 15,
Methylparaben, Proplyparaben…….yes it was just warm—no pain at
all……seriously thankyou for this information—I am 36 already with
erectile dynsfunction(a trauma injury damaged me down there)….so I already
have 1 big strike at my age—-I didnt need this one too 🙁 …….So even
though she stroked me for some minutes she must not have had enough
capsaicin on me to burn? Could I not have noticed the burn–ie stroking
feels good 🙂 ….or would I have really noticed it burning? Thankyou
Itty bitty 2007-09-27 10:44:19
If a dose of Jalepeno can cause nerve damage—why are people not walking
around with nerve damaged mouths?
Bilz0r 2007-09-28 10:19:39
Because they are. Havn’t you ever wondered why people who eat spicy food
very often can handle food a lot hotter than people who never eat spciy
Lurker 2007-09-28 10:19:41
I found these snippets too. May I ask _if_ my VR1 receptors are damaged what
are they—are they the pain receptors? pleasure? etc. I am kind of getting
confused. I really think I am hosed—I just have to believe that this has
happened to many more people. Again there was no burn. Just warm and well
maybe a little red. The next day I poured a quart of milk on it.
“The capsaicin receptor: a heat-activated ion channel in the pain pathway.”
The focus, Capsaicin, is a molecule found in the white “ribs” of hot peppers
that is the root of our perception of heat from the peppers. It is assumed
to be a defense mechanism in a variety of pepper plants. The capsaicin found
in hot peppers work by binding to and stimulating capsaicin receptor
proteins found in neuronal cells. The fibers of the neuronal cells then
carry the stimulus from areas such as the tongue, to the roots of the spinal
cord. Capsaicin also allows a deluge of calcium ions to enter the neuron.
This is dangerous, because an extended exposure to calcium causes the fibers
of the neuron to die.
The Summary of “The capsaicin receptor: a heat-activated ion channel in the
Capsaicin is a natural product of capsicum peppers, that is an active
ingredient in many hot foods. When nociceptors- neurons that transmit
information regarding tissue damage to pain-processing centers in the spinal
cord and brain- come in contact with capsaicin, the neuron gets excited, and
there is a perception of pain, and the a local release of inflammatory
mediators. These nociceptors get excited by increasing permeability of
plasma membrane to cations, but the molecular mechanism explaining this
phenomenon is unclear. Capsaicin is being used in an analgesic agent in the
treatment of painful disorders, causing long-term loss of responsiveness
because it kills off the nociceptor, or it destroys the peripheral
terminals. It was decide that the existence of a receptor site represents
the most likely mechanism, because the capsaicin derivative showed
structure-function relationships and evoked responses in a dose-dependent
manner. A competitive capsaicin antagonist called capsazepine strengthened
this model, along with discovering resiniferatoxin, an extremely potent
capsaicin analogue for Euphorbia plants that mimics the cellular action of
capsaicin. The cloning of a gene encoding a capsaicin receptor was decided
to help develop more understanding of the molecular nature of capsaicin
action and its relationship to endogenous pain signaling mechanisms. A cDNA
clone that reconstitutes capsaicin responsiveness in non-neuronal cells was
isolated. It was discovered that capsaicin gives off burning sensations
through the activation of a heat-gated ion channel that is likely to
contribute to the detection of painful thermal stimuli in vivo. Since the
molecular structure of capsaicin receptors was not known, the experimenters
adopted a functional screening strategy for isolating candidate cDNA clones.
Because capsaicin has the ability to trigger robust calcium influx into
sensory neurons in vitro, a cloning strategy was contrived. Since capsaicin
responsiveness seemed to be confined to nociceptive neurons with cell bodies
that resided within sensory ganglia, a cDNA library was constructed from
dorsal root ganglion-derived messenger RNA. The pools consisted of 16,000
clones in each, and was transfected in human embryonic kidney-derived
HEK193, and the transfected cells were filled with the fluorescent
calcium-sensitive dye Fura-2 (emits light when in contact with Calcium), and
examined for capsaicin-evoked changes in intracellular calcium levels. When
a positive pool was found, it was reassayed, repeating the process over and
over, until an individual clone containing a 3-kilobase cDNA insert was
weeded out, which conferred capsaicin or resiniferatoxin. It was determined
that this was the DNA-encoded aminoacid sequence of the protein that
comprises the capsaicin receptor. Since the vanilloid group chemically
represents capsaicin, it was called VR1. The scientists compared the
pharmacological properties of the cloned receptor to those of native
vanilloid sites in sensory ganglia. They examined the electrophysiological
responses to a variety of vanilloid agonaists and antagonists. It was
concluded that capsaicin and resiniferatoxin activate the current, while
capsazepine, and synthetic antagonist, blocks the current. It was suggested
that there is more that one binding site for the agonists molecule, which is
true with vanilloid receptors. Capsaicin is able to bind to a channel form
either the exterior or the interior of the plasma membrane. It was
discovered that the cell lines made to express VR1 die after several hours
of continuous exposure to capsaicin. The reason seems to be because of
injury, and the researchers think it is induced by the continuous influx of
ions. The reason for the death of cells when capsaicin is present in the
cell, is because the capsaicin opens the ion channel, letting calcium in.
When too much Calcium is let in, the cells die. It was suggested that
vanilloid receptors serve as specific molecular markers for nociceptive
neurons. Trigeminal and dorsal root sensory ganglia contain
capsaicin-sensitive neurons. They were not found in the spinal cord or
brain. Two other tissues that have been proposed to express capsaicin
receptors are the nodose ganglion and the preoptic area of the hypothalamus.
There was no detection of VR1 expression at these location, but vanilloid
responsiveness here might be conferred by distinct VR1 subtypes. There was a
hypothesis that VR1 is activated by noxious heat, and not innocuous heat. It
was found that rapid increases in temperature evoke ion currents from
expressed VR1 channels that closely mimic those induced by capsaicin.
Therefore the hypothesis was supported by the results.
Lurker 2007-09-29 16:35:26
Thankyou again for the input. So basically I _might_ be ok. ie the “redness”
was simply from the friction of the hand. The “warmness” was simply the
capsaicin–yet I _might_ not have got the dose I need to cause permanant
damage or desensitivity–even though it was left on for days and I simply
used soap and water to wash the heck out of it?? Is there any type of test
for this damage??
I apologize if I seem crazy to everyone. But my situation is kind of–hmm I
am not sure the word. I am 36 and have/had hypogonadism due to empty sella.
Unfortuneately it wasnt caught when I was growing up. I guess back then the
hormone treatment/mri’s just really wasnt there. As I result of this my
p**** never developed properly(some doctors I have been too differ). My
p**** is only about 2 inches flacid maybe 4 inches erect. So obviously that
was tough going through. When I started seeing doctors in my teen I was
simply giving testoserone injections—I believe I had free of 192(162) and
it was moved to the 700’s. Life goes on and doctors change and eventually it
was discovered I had extremely high prolactin and was given parlodel and
some other dopamine. Eventually My free stabilized to the 350’s. I developed
gynecomastia twice and had two surgeries for each breast. Of course with my
small size and whereever all my hormone levels finally settled too I was
always getting constant erections from 12yr to 35yrs. In my twenties I
contracted genital herpes—the one time I didnt use a condom with my then
gf. No biggie I got over that. That was the one time I have never used a
condom and has been since. Several years ago I contraced genital warts from
my then gf while using a condom(why my gf never told me they had this is
another story). Ok I got over that. Shortly after during intercourse once my
p**** missed the v***** and wow did that hurt. No penile fracture but I have
lost some erection potential(I am told my ED is from stress now). I had a
doppler done when I was flaccid and found good blood flow I am supposed to
have one soon when erect. The same gf then gave me the handjob with the
peppers unbenkowst to me. And that is where I am. So my little guy has been
through a lot—I can deal with everything but this possible loss of
sensitivity maybe my last straw!
Anyway my learnings through life for everyone: size doesnt matter—really.
that one took me awhile. If you have std’s be responsible and tell your
partner—I certainly do. If you have a penile injury from trauma and your
urologist simply says “take some v***** you are getting older”–find another
now for a glass of wine and off to bed!