Robinmst 2011-08-03 16:16:47
Host factors and failure of interferon-alpha treatment in hepatitis C
Hepatology. 2004 Apr;39(4):880-90.
Gao B, Hong F, Radaeva S.
Failure of interferon-alpha (IFN-alpha) treatment in patients with
chronic hepatitis C virus (HCV) infection is a challenging obstacle
for clinical and experimental hepatology. Both viral and host factors
have been implicated in reducing responsiveness to IFN-alpha therapy.
The role of viral factors has been studied extensively and has been
summarized in several review articles; however, much less attention
has been paid to host factors. In this paper, we review evidence of
host factor involvement in IFN-alpha treatment failure. We discuss
possible underlying mechanisms responsible for these effects.
Potential therapeutic strategies to enhance the effectiveness of
IFN-alpha therapy for HCV are also proposed.