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1 21st April 23:25
ree
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Posts: 1
Default Celebrex use in Dogs


Celebrex is one of the most useful drugs for treatment of osteoarthritis
in humans . Has anyone used it in dogs and have you seen any beneficial
results ? I know aspirin helps to some extent , but the newer NSAI drugs
are marvelous . TIA
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2 21st April 23:25
gwen watson
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Posts: 1
Default Celebrex use in Dogs


I think that depends on the degree of osteoarthritis. Celebrex
doens't do much for me. And on many web pages there
is indication that it is more or less a very expensive version
of Alieve. Celebrex and Vioxx only real claim to fame
is the fact they do not eat holes in your stomach lining
with long term use. That has been debunked as well.
Longterm use of either *can* cause stomach ulcerations.
Also they do damage to all vital organs, ie heart, liver,
and kidneys. There are many class action lawsuits over
both Celebrex and Vioxx.

As for NSAIDS for dogs there is Rimadyl and Metacam.

Both do have side effects and one must weigh the dogs quality
of life when opting for the use. There is definitely a time or
place for them and a need. But *many* will agree the use
of these medications will in the longrun shorten the life
of the dog. Still it will give them back a mostly painfree
quality of life.

http://www.pfizer.com/ah/mypet/mydog/dhealth/dripkg.html

And here is a blurb about the 3 most popular ones.

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

This website has extensive coverage on Rimadyl, a non-steroidal
anti-inflammatory drug (NSAID) used to relieve the symptoms of arthritis in
older dogs. Although the drug is extremely effective with many dogs, its
side effects can be serious. If you would like to learn more, visit the
Rimadyl page on this site. Other NSAIDs, such as Etogesic and aspirin, are
discussed below.

In addition to Rimadyl, there are other NSAID therapy choices, such as
aspirin and EtoGesic. Aspirin has a tendency to irritate the stomach, and,
according to the March 1998 issue of Dog World magazine, " . . . serious
side effects may result from the use of acetophenetidin (Phenacetin),
indomethacin (Indocin), pentazocine (Talwin), phenylvutazone (Butazolidin),
or piroxicam (Feldene)." Use these substances only as prescribed by a
veterinarian, and be extremely alert to signs of gastro-intestinal
side-effects such as vomiting and diarrhea.

According to the Merck Veterinary Manual, 1998 edition, aspirin dosage for
dogs is 10-25 mg. per kg. of body weight, PO, (orally) b.i.d. (twice per
day). To convert your dog's weight from lbs. to kg., multiply lbs. x 0.45.

Stomach upset and irritation can be minimized by using Ascriptin instead of
aspirin. However, enteric-coated aspirin, such as Ecotrin, may not be
effective because it is incompletely digested and absorbed by the dog's
system, causing erratic results. Drs. Foster & Smith sell "Buffered Canine
Aspirin," a timed-release capsule that is designed to be digested and
absorbed properly by a dog's system. In addition, it is liver flavored.
Approximate cost: 250 tablets of 120 mg for $7.99. (Drs. Foster & Smith
website and telephone noted under "Resources," linked from the navigation
column at the left.)

Naproxen (a prescription drug in use for 20 years with humans) is an
alternative to aspirin, if aspirin doesn't seem to work. Some dogs get
relief on a low dose given every other day. However, overdosing is a risk
because the tablet is quite large; the liquid form is better for small dogs.
GI bleeding and, in extreme cases, perforation are possible side effects
with chronic use.

Ibuprofen (Advil and Motrin) can cause serious problems in dogs; there is no
safe dosage. Acaetaminophen (Tylenol) is not an anti-inflammatory, and can
also have toxic effects on the liver. Dogs are more sensitive than humans to
drugs that are toxic to the liver, and Tylenol is known to have toxic
effects in humans. Don't use Tylenol for relief of arthritis pain in dogs.

EtoGesic acts like Rimadyl. It is also a non-steroidal anti-inflammatory. It
differs from Rimadyl in that it is given just once a day instead of twice.
It does have gastro-intestinal side effects in some dogs, however, as well
as dry eye syndrome and photosensitivity. There are some reports on EtoGesic
posted on this website. For more information, you may wish to call the
manufacturer, Fort Dodge Animal Health, 1- 800-477-1365, or to read the
package insert.

Some dogs respond better to Rimadyl than to EtoGesic, and vice versa. Either
drug can provide relief; either drug may cause side effects.

Fatalities have been reported in connection with Metacam, another
non-steroidal anti-inflammatory medication.

Deramaxx is the most recent entry in the canine NSAID market. It also has
the potential for harmful side effects. For more information on Deramaxx,
please visit the following sites:

http://home.insightbb.com/~e.murray/index.html

http://www.amedical.com/deramaxx.html

When using NSAID's it is best to to be especially alert to symptoms of
toxicity -- e.g., diarrhea or vomiting, excessive urination, lack of
appetite, lethargy, behavioral changes, etc. -- and to withdraw the
medication immediately should these symptoms appear. Remember, also, to ask
your veterinarian how to determine the lowest possible dosage that provides
relief, which will thereby lower the risk of toxicity.

Gwen
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3 22nd April 19:41
buglady
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Posts: 1
Default Celebrex use in Dogs


......All NSAIDs seem to erode the stomach after a while.
http://www.fda.gov/cder/consumerinfo/druginfo/celebrex.htm

http://www.marvistavet.com/html/body_deracoxib.html
Deracoxib represents the latest generation in the search for a pain reliever
with minimal side effects. The Coxib class of NSAIDs inhibits COX-2 with no
inhibition at all of COX-1. Deracoxib, produced by Novartis Animal Health,
is the first coxib class NSAID for animals, hoping to follow the wide
success of Celecoxib (Celebrex®) and rofecoxib (Vioxx®). The human drugs are
not very useful for dogs as metabolism is not predictable among individuals.
Deracoxib has a predictable duration of action and dose response in dogs.

Celebrex was used in a cancer ****tail for a dog named Navy:
http://www.usatoday.com/news/health/2002-07-24-cover-cancer_x.htm
When researchers heard that Navy was cancer-free after receiving a ****tail
of drugs already approved by the Food and Drug Administration — Celebrex,
tamoxifen (sold as Nolvadex) and doxycycline — the treatment became known as
the Navy Protocol.

buglady
take out the dog before replying
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4 23rd April 15:33
walternyc
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Posts: 1
Default Celebrex use in Dogs


It's an amazing product! Not for dogs but for the fact that for the
first time in history a natural substance found in aspirin was allowed
to be patented and trademarked. The approval came with lots of debate
but in the end they took the stuff that made .02 cent asprin work and
somehow got the governement to allow them to sell it at a much higher
price and then claim they 'owned' it. ANd even funnier was that
Celebrex was supposed to be relief of pain without the gastric side
effects. Problem was that in the first few months of its introduction,
Celebrex killed ten people from ulcers, heart attacks and one kidney
failure and caused eleven other serious cases of gastrointestinal
hemorrhages. So if you want the same results minus the cost, try
asprin. No one has prooved that the drugs do anything more than
asprin.
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5 24th April 11:12
spot
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Posts: 1
Default Celebrex use in Dogs


Absolutely DO NOT USE THIS IN DOGS. It is not made for animal use.

There are medications specifically made for dogs that work in the same way.
If your dog has arthritis and enteric aspirin is not helping enough with the
pain then it is time to see the vet about going with a prescription
medications. Some of the medications made for dogs are Rimadyl or Deramaxx.
The draw back is they can have side effects some of which are life
threatening. It's a decision of deciding is the pain causing quality of
life to be unbearable and if so are you willing to take the risk that
switching to a prescription medication may be beneficial or could it cause
bad liver or kidney problems.

Some dogs do wonderfully on these medications where others do not. My dog
Barney has had arthritis from bad knees and had ACL surgery on both knees
over the last 5 years. It came to a point that aspirin and supplements just
were not working any longer. I decided to go with the prescription
medications and it's made a 100 % difference in his life. He gets around
wonderfully is playful & back to his old self. There are still days where
we've been doing a bit too much and he's just plain tired at night and needs
a bit of help up the stairs but then he's almost 11 so it's expected at his
age.

Celeste
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