james michael howard

Evolution of Virulence: Lipopolysaccharide and Gram-negative organisms and DHEA

Copyright 2005; James Michael Howard, Fayetteville, Arkansas, U.S.A.

I happened onto this topic while researching another area. I am not a
microbiologist. I discovered that lipopolysaccharide causes a number of
pathological effects, everyone of which, I would have attributed to low DHEA.
(I am of the opinion that all tissues depend upon DHEA for optimal function and
think that mammals evolved as a result of selection for DHEA: “Hormones in
Mammalian Evolution,” Rivista di Biologia / Biology Forum 2001; 94: 177-184).
Eventually, I found the following which explains why the effects of
lipopolysaccharide may, indeed, cause the effects of low DHEA.
Lipopolysaccharide "markedly" depresses DHEAS sulfatase activity in another
study, therefore, blocking conversion to DHEA (Endocrinology. 1994
Jul;135(1):67-75).

I suggest that lipopolysaccharide was selected by evolution because it reduces
levels of DHEA and allows gram-negative organisms to avoid the immune response
of an organism with ample amounts of DHEA. DHEA improves the immune response.

g

Yes, there have been studies in support of its capacity to enhance the
immune response,
and to aid muscle tone, and to give rise to certain other responses, as
well.

However, as the world has learned quite recently, studies by a most famous
and previously
respected physician-researcher, on the benefits of estrogen therapy in
post-menopausal
females were fraudulently skewed. No doubt you have seen this on the news
within the
past 24-48 hours. Some women were found to be healthier than ever after
menopause.

What a horrendous blow to the credibility of all medical research, and what
a blatant
reminder that we should never fail to follow the advice echoed by the
headless "Deep
Throat" in the movie in which he said, "Follow the money."

We must be careful about putting too much faith in a single study by ANYONE
who has
a vested economic interest in the outcome. No stronger case can be made
than this one
for the reperformance of experiments by many, with hopes of exposing
subjectivity, greed
and egregious manipulations of research results for any reason.

We may speculate all we want, and believe whomever we prefer to believe, and
leap to
any conclusion we prefer as to what we shall or shall not put into our
bodies. But the
actual consequences will be what they shall be, and not what an advertiser
would have us
believe that is in his own best interest.

g

james michael howard

g, that is a lot of response about nothing concerning my post. I cannot
understand the reason for your response.

g

Boredom.

Will try to put a muzzle on it.

(:>)

g