peter f.

Baby-mice that were genetically engineered to be mu-opioid receptor-free
don't get distressed by being deserted by their mothers (nor or by being
dealt a different one by the experimenters).

Another way or describing this psychobehavioral effect is, that this
particular gene manipulation caused a "psychobiological needlessness"
coupled with a specifically correlated painlessness in situations (or in
respect of lifetime stressors) that to normal ("mu-opioid receptor gene
intact") baby mice would be seriously distressing.

A question that may be asked is: What is the coding function of this gene?

It is plausible that NOT ONLY does it code (or provide a recipe-like
instruction) for a pain-controlling mechanism (one in which both opioid
transmitters and receptors are known to be "key cogs") that achieves (most
notably in certain slowly traumatic situations) a state of suppression of
pain or distress (IOW, that allows "synaptic/selective hibernation") BUT
that it is also a genetic instruction for the forming - by way of
Waddingtonian "genetic c****ization" - of the neural hardware behind THE
VERY kind of fundamental PSYCHOBIOLOGICAL NEED that when not environmentally
fulfilled will primarily endogenously motivate a corresponding pain or
distress.

In the same light, this gene (presumably arisen in our own as well as mice's
phylogeny) that has now been identified as the "mu-opioid receptor gene" -
for lack of a more complete understanding of its role, may be used (by me)
to exemplify: the principle of "ambi-advantageous" (ambi-advantageously
adaptive and ditto functure-forming) mutation in the phylogeny of fauna; and
the strange attractor within animal evolution in the direction of "AEVASIVE
genophenotypes" - an logical, and by Natural Laws led, evolutionary
patterning tendency (as if a subprinciple of Darwinian "Natural Selection")
that seem to have reached its most extreme and elaborate phenotypic
manifestation in the form of the AEVASIVE psychological and cultural
characteristics of our own species.

P

me again

[Apropos an article I recently read in New Scientist.]

Baby mice who by genetic engineering are mu-opioid receptor free,
don't get distressed by being deserted by their mothers nor by being
dealt a different one (i.e., a stand-in mother).

Another way or describing this psychobehavioral effect is, that this
particular gene manipulation causes this "psychobiological needlessness"
and a close correlated painlessness in situations (or in
respect of lifetime stressors) that to normal ("mu-opioid receptor gene
intact") baby mice would be seriously distressing.

A question that may be asked is: What is the coding function of this gene?

It is plausible that NOT ONLY does it code (or provide a recipe-like
instruction) for a pain controlling mechanism (one in which both opioid
transmitters and receptors are known to be "key cogs") that achieves (most
notably in certain slowly traumatic situations) a state of suppression of
pain or distress (IOW, allows synaptic/selective "hibernation" of slow
traumas) BUT
that it also instructs the forming - by way of
Waddingtonian "genetic c****ization" - of the neural hardware behind THE
CORRESPONDING KIND OF PRIMAL PSYCHOBIOLOGICAL NEED;
A need that when not environmentally fulfilled will primarily endogenously
motivate a corresponding pain or distress.

In the same light, this gene (presumably arisen in the phylogeny of both
mice and men), that has now been identified as the "mu-opioid receptor gene"
(for lack of a more complete understanding of its more extensive role), can
be referred to as an example of the tendency for (principle of)
"ambi-advantageous" (ambi-advantageously adaptive) and ditto 'functure
forming' [functure=functional structure] mutations to have a competitive
advantage in the phylogeny of fauna.
Moreover it can illustrate what constitutes a strange attractor within
animal evolution in the direction of "AEVASIVE" genophenotypes.

AEVASIVE genophenotypes is a logical, and by Natural Laws led, evolutionary
patterning-tendency (a subprinciple of Darwin's super-principle, which is
"natural selection")
that seem to have reached its most extreme and elaborate phenotypic
manifestation in the form of the AEVASIVE psychological and cultural
characteristics of our own species.

[AEVASIVE pragmatically stand for: Ambi-advantageously Evolved Veritable
Actention (Selection) System Incorporating Various Endoopiates.]

P

P.S. More information, about what other uniquely formulated to be
excEPTionally edutaining "concEPTs" of my effectively philosophy
terminating explanatory platform-terminology, is freely available.

However, unless you are a septic humored, intellectually aggressive, insight
seeking, philosophically inclined pundit, my prognosis is that most of my
concEPTs will get too far up your nose. %-)
D.S.